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Jerome Rotter

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Articles 12
Citations 187
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Recent Articles
1.
Raffield L, Nicholas J, Katz D, Nicholas J, Tahir U, Katz D, et al.
Res Sq . 2025 Feb; PMID: 39989965
Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants (pQTL) and phenotypes. Here, we examined 2,157 proteins measured on both SomaScan 7k and Olink...
2.
Sedaghat S, Park S, Walker R, Wang S, Liu J, Hughes T, et al.
Res Sq . 2025 Jan; PMID: 39877085
Background: Biological age can be quantified by composite proteomic scores, called aging clocks. We investigated whether biological age acceleration (a discrepancy between chronological and biological age) in midlife and late-life...
3.
Chen J, Cammann D, Liu T, Liu Y, Cummings M, Chen X, et al.
Res Sq . 2025 Jan; PMID: 39764106
The global outbreak of COVID-19, caused by the SARS-CoV-2 virus, has been linked to long-term neurological complications, including an increased risk of Alzheimer's disease (AD) among older adults. However, the...
4.
Wang H, Nagarajan P, Winkler T, Bentley A, Miller C, Kraja A, et al.
Res Sq . 2024 Jul; PMID: 39070651
Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we...
5.
Debette S, Caro I, Western D, Namba S, Sun N, Kawaguchi S, et al.
Res Sq . 2024 Jul; PMID: 39011113
Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific mechanism-based treatment. We used Mendelian randomization to combine a unique cerebrospinal fluid (CSF) and...
6.
Manning A, Sevilla-Gonzalez M, Smith K, Wang N, Jensen A, Litkowski E, et al.
Res Sq . 2023 Oct; PMID: 37790568
Hyperinsulinemia is a complex and heterogeneous phenotype that characterizes molecular alterations that precede the development of type 2 diabetes (T2D). It results from a complex combination of molecular processes, including...
7.
Manichaikul A, Hu X, Logan J, Kwon Y, Lima J, Jacobs D, et al.
Res Sq . 2023 Jul; PMID: 37502922
Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding...
8.
Li Y, Wang M, Liu X, Rong J, Miller P, Joehanes R, et al.
medRxiv . 2023 Jul; PMID: 37398015
Background: Metabolite signatures of long-term alcohol consumption are lacking. To better understand the molecular basis linking alcohol drinking and cardiovascular disease (CVD), we investigated circulating metabolites associated with long-term alcohol...
9.
Rotter J, Li X, Owen L, Taylor K, Ostmo S, Chen Y, et al.
Res Sq . 2023 Jun; PMID: 37292936
We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-risk infants for retinopathy of prematurity (ROP), a major cause of childhood blindness, identifying 2 loci at...
10.
Kramer H, Stilp A, Laurie C, Reiner A, Lash J, Daviglus M, et al.
J Am Soc Nephrol . 2016 Sep; 28(3):915-922. PMID: 27650483
African ancestry alleles may contribute to CKD among Hispanics/Latinos, but whether associations differ by Hispanic/Latino background remains unknown. We examined the association of CKD measures with African ancestry-specific alleles that...