Jerome Jatzlau
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Explore the profile of Jerome Jatzlau including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
150
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Recent Articles
1.
Jatzlau J, Do S, Mees R, Mendez P, Khan R, Maas L, et al.
BMC Biol
. 2025 Mar;
23(1):79.
PMID: 40082964
Background: Receptor-activated SMADs trimerize with SMAD4 to regulate context-dependent target gene expression. However, the presence of a single SMAD1/5/8 binding motif in cis-regulatory elements alone does not trigger transcription in...
2.
Ugorets V, Mendez P, Zagrebin D, Russo G, Kerkhoff Y, Kotsaris G, et al.
iScience
. 2024 Sep;
27(9):110630.
PMID: 39246450
Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells. The transformation of proliferative muscle progenitors...
3.
Ilhan M, Hastar N, Kampfrath B, Spierling D, Jatzlau J, Knaus P
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38731813
Increased expression and nuclear translocation of β-CATENIN is frequently observed in breast cancer, and it correlates with poor prognosis. Current treatment strategies targeting β-CATENIN are not as efficient as desired....
4.
Szilagyi S, Burdzinski W, Jatzlau J, Ehrlich M, Knaus P, Henis Y
Cells
. 2024 Feb;
13(3.
PMID: 38334613
Mutations in activin-like kinase 2 (ALK2), e.g., ALK2-R206H, induce aberrant signaling to SMAD1/5/8, leading to Fibrodysplasia Ossificans Progressiva (FOP). In spite of extensive studies, the underlying mechanism is still unclear....
5.
Raaz L, Mendez P, Mundlos S, Knaus P, Jatzlau J
STAR Protoc
. 2024 Feb;
5(1):102859.
PMID: 38329877
Chromatin accessibility influences gene regulation and can be quantified using assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). Recapitulating in vivo fluid shear stress (FSS) mechano-regimes in vitro allows the...
6.
Melo U, Jatzlau J, Prada-Medina C, Flex E, Hartmann S, Ali S, et al.
Nat Commun
. 2023 Oct;
14(1):6301.
PMID: 37813867
No abstract available.
7.
Trumpp M, Tan W, Burdzinski W, Basler Y, Jatzlau J, Knaus P, et al.
PLoS One
. 2023 Sep;
18(9):e0291379.
PMID: 37708126
Activin and Bone Morphogenetic Protein (BMP) signaling plays crucial roles in vertebrate organ formation, including osteo- and angiogenesis, and tissue homeostasis, such as neuronal maintenance. Activin and BMP signaling needs...
8.
Jatzlau J, Mendez P, Altay A, Raaz L, Zhang Y, Mahr S, et al.
iScience
. 2023 Sep;
26(9):107405.
PMID: 37680470
Bone morphogenetic protein (BMP) signaling and fluid shear stress (FSS) mediate complementary functions in vascular homeostasis and disease development. It remains to be shown whether altered chromatin accessibility downstream of...
9.
Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
Melo U, Jatzlau J, Prada-Medina C, Flex E, Hartmann S, Ali S, et al.
Nat Commun
. 2023 Apr;
14(1):2034.
PMID: 37041138
Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in which signaling pathways such as BMP, TGFβ and WNT are known key players in driving ectopic bone...
10.
Quist-Lokken I, Andersson-Rusch C, Kastnes M, Kolos J, Jatzlau J, Hella H, et al.
Cell Commun Signal
. 2023 Jan;
21(1):25.
PMID: 36717825
Background: The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls...