Jerome Jatzlau
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Explore the profile of Jerome Jatzlau including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
150
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Recent Articles
11.
Jatzlau J, Burdzinski W, Trumpp M, Obendorf L, Rossmann K, Ravn K, et al.
Commun Biol
. 2023 Jan;
6(1):34.
PMID: 36635368
TGFβs, BMPs and Activins regulate numerous developmental and homeostatic processes and signal through hetero-tetrameric receptor complexes composed of two types of serine/threonine kinase receptors. Each of the 33 different ligands...
12.
Mendez P, Obendorf L, Jatzlau J, Burdzinski W, Reichenbach M, Nageswaran V, et al.
BMC Biol
. 2022 Sep;
20(1):210.
PMID: 36171573
Background: Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate SMAD1/5 activation is required to maintain endothelial quiescence, excessive...
13.
Reichenbach M, Mendez P, da Silva Madaleno C, Ugorets V, Rikeit P, Boerno S, et al.
Adv Biol (Weinh)
. 2022 Sep;
5(2):e2000051.
PMID: 36073990
Bone is a remarkable dynamic structure, which integrates mechanical and biochemical signaling inputs. Interstitial fluid in the intramedullary space transmits signals derived from compression-induced fluid shear stress (FSS) to stimulate...
14.
Kolos J, Pomplun S, Jung S, Riess B, Purder P, Voll A, et al.
Chem Sci
. 2021 Nov;
12(44):14758-14765.
PMID: 34820091
Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group...
15.
da Silva Madaleno C, Jatzlau J, Knaus P
Bone
. 2020 May;
137:115416.
PMID: 32422297
Bone Morphogenetic Proteins (BMPs) are extracellular multifunctional signalling cytokines and members of the TGFβ super family. These pleiotropic growth factors crucially promote bone formation, remodeling and healing after injury. Additionally,...
16.
Hiepen C, Jatzlau J, Knaus P
Cell Stress
. 2020 Feb;
4(2):44-47.
PMID: 32043077
Cardiovascular disorders are still the leading cause for mortality in the western world and challenge economies with steadily increasing healthcare costs. Understanding the precise molecular pathomechanisms behind and identifying players...
17.
Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al.
PLoS Biol
. 2019 Dec;
17(12):e3000557.
PMID: 31826007
Balanced transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP)-signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is often found in diseases, the underlying cellular mechanisms remain...
18.
Brunner P, Hastar N, Kaehler C, Burdzinski W, Jatzlau J, Knaus P
Mol Biol Cell
. 2019 Dec;
31(2):118-130.
PMID: 31800378
The large isoform of the transmembrane protein angiomotin (AMOT130) controls cell proliferation and migration of many cell types. AMOT130 associates to the actin cytoskeleton and regulates tight-junction maintenance and signaling...
19.
Dorpholz G, Murgai A, Jatzlau J, Horbelt D, Belverdi M, Heroven C, et al.
Sci Rep
. 2017 Aug;
7(1):8778.
PMID: 28821740
Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP...