Jeroen Pouwels
Overview
Explore the profile of Jeroen Pouwels including associated specialties, affiliations and a list of published articles.
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31
Citations
660
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Recent Articles
11.
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex
Khan M, Salomaa S, Jacquemet G, Butt U, Miihkinen M, Deguchi T, et al.
J Cell Sci
. 2017 Aug;
130(18):3094-3107.
PMID: 28775156
Sharpin, a multifunctional adaptor protein, regulates several signalling pathways. For example, Sharpin enhances signal-induced NF-κB signalling as part of the linear ubiquitin assembly complex (LUBAC) and inhibits integrins, the T...
12.
Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, et al.
Nat Cell Biol
. 2017 Mar;
19(4):292-305.
PMID: 28263956
SHANK3, a synaptic scaffold protein and actin regulator, is widely expressed outside of the central nervous system with predominantly unknown function. Solving the structure of the SHANK3 N-terminal region revealed...
13.
De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel A, Wilson T, et al.
Nat Struct Mol Biol
. 2017 Feb;
24(2):194.
PMID: 28169997
No abstract available.
14.
De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel A, Wilson T, et al.
Nat Struct Mol Biol
. 2016 Jan;
23(2):172-9.
PMID: 26779610
Integrins are heterodimeric cell-surface adhesion molecules comprising one of 18 possible α-chains and one of eight possible β-chains. They control a range of cell functions in a matrix- and ligand-specific...
15.
De Franceschi N, Peuhu E, Parsons M, Rissanen S, Vattulainen I, Salmi M, et al.
PLoS One
. 2015 Nov;
10(11):e0143423.
PMID: 26600301
SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of the linear ubiquitin chain assembly...
16.
Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, et al.
Dev Cell
. 2015 Aug;
34(4):475-83.
PMID: 26256210
Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet proteins required for the internalization...
17.
Pouwels J, De Franceschi N, Rantakari P, Auvinen K, Karikoski M, Mattila E, et al.
Cell Rep
. 2013 Nov;
5(3):619-28.
PMID: 24210817
SHARPIN-deficient mice display a multiorgan chronic inflammatory phenotype suggestive of altered leukocyte migration. We therefore studied the role of SHARPIN in lymphocyte adhesion, polarization, and migration. We found that SHARPIN...
18.
Hamalisto S, Pouwels J, De Franceschi N, Saari M, Ivarsson Y, Zimmermann P, et al.
PLoS One
. 2013 Aug;
8(8):e70696.
PMID: 23967087
Recently, we demonstrated that integrin adhesion to the extracellular matrix at the cleavage furrow is essential for cytokinesis of adherent cells. Here, we report that tight junction protein ZO-1 (Zonula...
19.
Bouvard D, Pouwels J, De Franceschi N, Ivaska J
Nat Rev Mol Cell Biol
. 2013 May;
14(7):430-42.
PMID: 23719537
Integrins mediate cell-matrix and cell-cell interactions and integrate extracellular cues to the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is regulated by their activity switching such...
20.
Salmela A, Pouwels J, Maki-Jouppila J, Kohonen P, Toivonen P, Kallio L, et al.
Carcinogenesis
. 2012 Oct;
34(2):436-45.
PMID: 23104179
Mitosis represents a clinically important determination point in the life cycle of proliferating cells. One potential drug target within the mitotic machinery is the spindle assembly checkpoint (SAC), an evolutionarily...