Jeremy W Chambers
Overview
Explore the profile of Jeremy W Chambers including associated specialties, affiliations and a list of published articles.
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30
Citations
677
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Recent Articles
1.
Rezaei S, Moncada-Restrepo M, Leng S, Chambers J, Leng F
bioRxiv
. 2025 Feb;
PMID: 39896529
Supercoiled (Sc) circular DNA, such as plasmids, has shown therapeutic potential since the 1990s, but is limited by bacterial modifications, unnecessary DNA sequences, and contaminations that may trigger harmful responses....
2.
Su L, Deng Z, Santos-Fernandez M, Jeanne Dit Fouque K, Chapagain P, Chambers J, et al.
Nucleic Acids Res
. 2025 Jan;
53(3).
PMID: 39873271
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a small DNA-binding protein that specifically targets AT-rich DNA sequences. Structurally, HMGA2 is an intrinsically disordered protein (IDP), comprising three...
3.
Bilkis K, Khalaf M, Fink D, Chambers J, Logue B
J Pharm Biomed Anal
. 2025 Jan;
255:116650.
PMID: 39793368
Organophosphorus (OP) pesticides (e.g., parathion) and nerve agents (e.g., soman) can produce acute and long-term neurological problems. Exposure to OP chemicals is responsible for an estimated 200,000 deaths annually. Pz-1...
4.
Godieva V, Sammoura F, Verrier Paz S, Han Y, Di Guida V, Rishel M, et al.
bioRxiv
. 2024 Jan;
PMID: 38293240
The c-Jun N-terminal kinase 3 (JNK3) is a stress-responsive protein kinase primarily expressed in the central nervous system (CNS). JNK3 exhibits nuanced neurological activities, such as roles in behavior, circadian...
5.
Azmoun S, Diaz Y, Tang C, Horton M, Clouston S, Luft B, et al.
Adv Neurotoxicol
. 2023 Sep;
7:29-45.
PMID: 37663650
No abstract available.
6.
Alfonso E, Deng Z, Boaretto D, Hood B, Vasile S, Smith L, et al.
ACS Pharmacol Transl Sci
. 2022 Oct;
5(10):932-944.
PMID: 36268121
Bacterial DNA gyrase, a type IIA DNA topoisomerase that plays an essential role in bacterial DNA replication and transcription, is a clinically validated target for discovering and developing new antibiotics....
7.
Bales B, Cotero V, Meyer D, Roberts J, Rodriguez-Silva M, Siclovan T, et al.
ACS Med Chem Lett
. 2022 Oct;
13(10):1606-1614.
PMID: 36262398
The c-Jun N-terminal kinase 3 (JNK3) is a stress-activated kinase primarily expressed in the brain and implicated as an early mediator of neuronal apoptosis. We sought to develop a PET...
8.
Balachandar L, Montejo K, Castano E, Perez M, Moncion C, Chambers J, et al.
Curr Protoc Neurosci
. 2020 Dec;
94(1):e110.
PMID: 33285041
Astrocytes are actively involved in a neuroprotective role in the brain, which includes scavenging reactive oxygen species to minimize tissue damage. They also modulate neuroinflammation and reactive gliosis prevalent in...
9.
Loth M, Guariglia S, Re D, Perez J, Nunes de Paiva V, Dziedzic J, et al.
Mol Neurobiol
. 2020 Aug;
57(11):4467-4487.
PMID: 32743737
In the brain neuropil, translocator protein 18 kDa (TSPO) is a stress response protein that is upregulated in microglia and astrocytes in diverse central nervous system pathologies. TSPO is widely...
10.
Wang Y, Rakela S, Chambers J, Hua Z, Muller M, Nitiss J, et al.
ACS Omega
. 2019 Nov;
4(19):18413-18422.
PMID: 31720544
DNA topoisomerases are essential enzymes for all living organisms and important targets for anticancer drugs and antibiotics. Although DNA topoisomerases have been studied extensively, steady-state kinetics has not been systematically...