Jeremy P Hasseman
Overview
Explore the profile of Jeremy P Hasseman including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
1465
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0
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Recent Articles
1.
Aggarwal A, Liu R, Chen Y, Ralowicz A, Bergerson S, Tomaska F, et al.
Nat Methods
. 2023 May;
20(6):925-934.
PMID: 37142767
The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo signal-to-noise ratios, saturating activation kinetics and exclusion from...
2.
Abdelfattah A, Zheng J, Singh A, Huang Y, Reep D, Tsegaye G, et al.
Neuron
. 2023 Apr;
111(10):1547-1563.e9.
PMID: 37015225
The ability to optically image cellular transmembrane voltages at millisecond-timescale resolutions can offer unprecedented insight into the function of living brains in behaving animals. Here, we present a point mutation...
3.
Zhang Y, Rozsa M, Liang Y, Bushey D, Wei Z, Zheng J, et al.
Nature
. 2023 Mar;
615(7954):884-891.
PMID: 36922596
Calcium imaging with protein-based indicators is widely used to follow neural activity in intact nervous systems, but current protein sensors report neural activity at timescales much slower than electrical signalling...
4.
Magloire V, Savtchenko L, Jensen T, Sylantyev S, Kopach O, Cole N, et al.
Curr Biol
. 2023 Mar;
33(7):1249-1264.e7.
PMID: 36921605
Mechanisms that entrain and pace rhythmic epileptiform discharges remain debated. Traditionally, the quest to understand them has focused on interneuronal networks driven by synaptic GABAergic connections. However, synchronized interneuronal discharges...
5.
Dana H, Sun Y, Mohar B, Hulse B, Kerlin A, Hasseman J, et al.
Nat Methods
. 2019 Jun;
16(7):649-657.
PMID: 31209382
Calcium imaging with genetically encoded calcium indicators (GECIs) is routinely used to measure neural activity in intact nervous systems. GECIs are frequently used in one of two different modes: to...
6.
Dana H, Mohar B, Sun Y, Narayan S, Gordus A, Hasseman J, et al.
Elife
. 2016 Mar;
5.
PMID: 27011354
Genetically encoded calcium indicators (GECIs) allow measurement of activity in large populations of neurons and in small neuronal compartments, over times of milliseconds to months. Although GFP-based GECIs are widely...
7.
Wardill T, Chen T, Schreiter E, Hasseman J, Tsegaye G, Fosque B, et al.
PLoS One
. 2013 Oct;
8(10):e77728.
PMID: 24155972
Fluorescent protein-based sensors for detecting neuronal activity have been developed largely based on non-neuronal screening systems. However, the dynamics of neuronal state variables (e.g., voltage, calcium, etc.) are typically very...
8.
Within the fold: assessing differential expression measures and reproducibility in microarray assays
Yang I, Chen E, Hasseman J, Liang W, Frank B, Wang S, et al.
Genome Biol
. 2002 Nov;
3(11):research0062.
PMID: 12429061
Background: 'Fold-change' cutoffs have been widely used in microarray assays to identify genes that are differentially expressed between query and reference samples. More accurate measures of differential expression and effective...