Karel Svoboda
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Explore the profile of Karel Svoboda including associated specialties, affiliations and a list of published articles.
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176
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29481
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Recent Articles
1.
Lakunina A, Socha K, Ladd A, Bowen A, Chen S, Colonell J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975326
High-resolution extracellular electrophysiology is the gold standard for recording spikes from distributed neural populations, and is especially powerful when combined with optogenetics for manipulation of specific cell types with high...
2.
Kaku H, Liu L, Gao R, West S, Liao S, Finkelstein A, et al.
bioRxiv
. 2025 Feb;
PMID: 39975015
Rhythmic orofacial movements, such as eating, drinking, or vocalization, are controlled by distinct premotor oscillator networks in the brainstem. Orofacial movements must be coordinated with rhythmic breathing to avoid aspiration...
3.
Wagenmaker A, Mi L, Rozsa M, Bull M, Svoboda K, Daie K, et al.
ArXiv
. 2024 Dec;
PMID: 39679275
Recent advances in techniques for monitoring and perturbing neural populations have greatly enhanced our ability to study circuits in the brain. In particular, two-photon holographic optogenetics now enables precise photostimulation...
4.
Amsalem O, Inagaki H, Yu J, Svoboda K, Darshan R
Nat Commun
. 2024 Sep;
15(1):7958.
PMID: 39261492
Cortical neurons exhibit temporally irregular spiking patterns and heterogeneous firing rates. These features arise in model circuits operating in a 'fluctuation-driven regime', in which fluctuations in membrane potentials emerge from...
5.
Pereira-Obilinovic U, Hou H, Svoboda K, Wang X
Proc Natl Acad Sci U S A
. 2024 Mar;
121(14):e2318521121.
PMID: 38551832
During foraging behavior, action values are persistently encoded in neural activity and updated depending on the history of choice outcomes. What is the neural mechanism for action value maintenance and...
6.
Chen S, Liu Y, Wang Z, Colonell J, Liu L, Hou H, et al.
Cell
. 2024 Feb;
187(3):676-691.e16.
PMID: 38306983
Behavior relies on activity in structured neural circuits that are distributed across the brain, but most experiments probe neurons in a single area at a time. Using multiple Neuropixels probes,...
7.
Mich J, Sunil S, Johansen N, Martinez R, Leytze M, Gore B, et al.
bioRxiv
. 2023 Oct;
PMID: 37790503
Proper brain function requires the assembly and function of diverse populations of neurons and glia. Single cell gene expression studies have mostly focused on characterization of neuronal cell diversity; however,...
8.
Buccino A, Winter O, Bryant D, Feng D, Svoboda K, Siegle J
J Neural Eng
. 2023 Aug;
20(5).
PMID: 37651998
With the rapid adoption of high-density electrode arrays for recording neural activity, electrophysiology data volumes within labs and across the field are growing at unprecedented rates. For example, a one-hour...
9.
Daie K, Fontolan L, Druckmann S, Svoboda K
bioRxiv
. 2023 Aug;
PMID: 37577599
The activity of single neurons encodes behavioral variables, such as sensory stimuli (Hubel & Wiesel 1959) and behavioral choice (Britten et al. 1992; Guo et al. 2014), but their influence...
10.
Glaser A, Chandrashekar J, Vasquez S, Arshadi C, Ouellette N, Jiang X, et al.
bioRxiv
. 2023 Jul;
PMID: 37425699
Recent advances in tissue processing, labeling, and fluorescence microscopy are providing unprecedented views of the structure of cells and tissues at sub-diffraction resolutions and near single molecule sensitivity, driving discoveries...