Jeremy M Murray
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Explore the profile of Jeremy M Murray including associated specialties, affiliations and a list of published articles.
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18
Citations
343
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Recent Articles
1.
Dragovich P, Pillow T, Blake R, Sadowsky J, Adaligil E, Adhikari P, et al.
J Med Chem
. 2021 Feb;
64(5):2576-2607.
PMID: 33596073
Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a targeted manner via co-opted ubiquitin ligases have enormous potential to transform the field of medicinal chemistry. These chimeric molecules,...
2.
Wertz I, Murray J
Drug Discov Today Technol
. 2019 Jun;
31:109-123.
PMID: 31200854
The Ubiquitin/Proteasome System comprises an essential cellular mechanism for regulated protein degradation. Ubiquitination may also promote the assembly of protein complexes that initiate intracellular signaling cascades. Thus, proper regulation of...
3.
Di Lello P, Pastor R, Murray J, Blake R, Cohen F, Crawford T, et al.
J Med Chem
. 2017 Nov;
60(24):10056-10070.
PMID: 29166018
USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason it has gained increasing attention as a potential oncology target for small molecule inhibitors. Herein...
4.
Safina B, Elliott R, Forrest A, Heald R, Murray J, Nonomiya J, et al.
ACS Med Chem Lett
. 2017 Sep;
8(9):936-940.
PMID: 28947940
A novel selective benzoxazepin inhibitor of PI3Kδ has been discovered. Beginning from compound , an αPI3K inhibitor, we utilized structure-based drug design and computational analysis of dihedral torsion angles to...
5.
Noland C, Kattke M, Diao J, Gloor S, Pantua H, Reichelt M, et al.
Proc Natl Acad Sci U S A
. 2017 Jul;
114(30):E6044-E6053.
PMID: 28698362
Gram-negative bacteria express a diverse array of lipoproteins that are essential for various aspects of cell growth and virulence, including nutrient uptake, signal transduction, adhesion, conjugation, sporulation, and outer membrane...
6.
Safina B, Sweeney Z, Li J, Chan B, Bisconte A, Carrera D, et al.
Bioorg Med Chem Lett
. 2013 Jul;
23(17):4953-9.
PMID: 23867164
In an effort to identify potent and isoform selective inhibitors of PI3Kδ, GNE-293 (34) was identified. Inhibitor 2 was found to induce micronuclei formation in both the MNT and HCA...
7.
Phillips A, Zhang Y, Cunningham C, Zhou L, Forrest W, Liu P, et al.
Proc Natl Acad Sci U S A
. 2013 Jun;
110(28):11379-84.
PMID: 23801757
Ubiquitin is a highly conserved eukaryotic protein that interacts with a diverse set of partners to act as a cellular signaling hub. Ubiquitin's conformational flexibility has been postulated to underlie...
8.
Zhang Y, Zhou L, Rouge L, Phillips A, Lam C, Liu P, et al.
Nat Chem Biol
. 2012 Nov;
9(1):51-8.
PMID: 23178935
Protein conformation and function are often inextricably linked, such that the states a protein adopts define its enzymatic activity or its affinity for various partners. Here we combine computational design...
9.
Labadie S, Dragovich P, Barrett K, Blair W, Bergeron P, Chang C, et al.
Bioorg Med Chem Lett
. 2012 Oct;
22(24):7627-33.
PMID: 23107482
Herein we describe our successful efforts in obtaining C-2 substituted imidazo-pyrrolopyridines with improved JAK1 selectivity relative to JAK2 by targeting an amino acid residue that differs between the two isoforms...
10.
Koth C, Murray J, Mukund S, Madjidi A, Minn A, Clarke H, et al.
Proc Natl Acad Sci U S A
. 2012 Aug;
109(36):14393-8.
PMID: 22908259
Members of the class B family of G protein-coupled receptors (GPCRs) bind peptide hormones and have causal roles in many diseases, ranging from diabetes and osteoporosis to anxiety. Although peptide,...