Jeremy C Santamaria
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Explore the profile of Jeremy C Santamaria including associated specialties, affiliations and a list of published articles.
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9
Citations
50
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Recent Articles
1.
Santamaria J, Chevallier J, Dutour L, Picart A, Kergaravat C, Cieslak A, et al.
Sci Transl Med
. 2024 Dec;
16(776):eadp3171.
PMID: 39630886
Age-related thymic involution, leading to reduced T cell production, is one of the major causes of immunosenescence. This results in an increased susceptibility to cancers, infections, and autoimmunity and in...
2.
Borelli A, Santamaria J, Zamit C, Apert C, Chevallier J, Pierre P, et al.
Nat Commun
. 2024 Aug;
15(1):6976.
PMID: 39143070
Regulatory T cells (T) are critical players of immune tolerance that develop in the thymus via two distinct developmental pathways involving CD25Foxp3 and CD25Foxp3 precursors. However, the mechanisms regulating the...
3.
Santamaria J, Vuillier S, Galindo-Albarran A, Castan S, Detraves C, Joffre O, et al.
Front Immunol
. 2024 Feb;
15:1358459.
PMID: 38404576
Regulatory T lymphocytes expressing the transcription factor Foxp3 (Tregs) play an important role in the prevention of autoimmune diseases and other immunopathologies. Aberrations in Treg-mediated immunosuppression are therefore thought to...
4.
Apert C, Galindo-Albarran A, Castan S, Detraves C, Michaud H, McJannett N, et al.
Front Immunol
. 2022 Sep;
13:965303.
PMID: 36159793
Development of Foxp3-expressing regulatory T-lymphocytes (Treg) in the thymus is controlled by signals delivered in T-cell precursors the TCR, co-stimulatory receptors, and cytokine receptors. In absence of IL-2, IL-15 or...
5.
Charaix J, Borelli A, Santamaria J, Chasson L, Giraud M, Serge A, et al.
Cell Mol Life Sci
. 2022 Jun;
79(7):355.
PMID: 35678896
Thymically-derived Foxp3 regulatory T cells (T) critically control immunological tolerance. These cells are generated in the medulla through high affinity interactions with medullary thymic epithelial cells (mTEC) expressing the Autoimmune...
6.
Lopes N, Boucherit N, Santamaria J, Provin N, Charaix J, Ferrier P, et al.
Elife
. 2022 Feb;
11.
PMID: 35188458
Interactions of developing T cells with Aire medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEC) are critical for the induction of central tolerance in the thymus. In...
7.
Galindo-Albarran A, Castan S, Santamaria J, Joffre O, Haegeman B, Romagnoli P, et al.
Diabetes
. 2021 May;
70(8):1729-1737.
PMID: 34035042
Regulatory T lymphocytes expressing the forkhead/winged helix transcription factor Foxp3 (Treg) play a vital role in the protection of the organism from autoimmune disease and other immunopathologies. The antigen specificity...
8.
Santamaria J, Borelli A, Irla M
Front Immunol
. 2021 Mar;
12:643153.
PMID: 33643324
Foxp3 regulatory T cells (Treg) maintain the integrity of the organism by preventing excessive immune responses. These cells protect against autoimmune diseases but are also important regulators of other immune...
9.
Darrigues J, Santamaria J, Galindo-Albarran A, Robey E, Joffre O, van Meerwijk J, et al.
Eur J Immunol
. 2020 Jul;
51(3):580-593.
PMID: 32730634
Regulatory T lymphocytes (Treg) play a vital role in the protection of the organism against autoimmune pathology. It is therefore paradoxical that comparatively large numbers of Treg were found in...