Jere P Segrest
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Explore the profile of Jere P Segrest including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
1058
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Recent Articles
1.
Sarkar S, Morris J, You Y, Sexmith H, Street S, Thibert S, et al.
J Lipid Res
. 2024 Nov;
65(12):100686.
PMID: 39490930
The ability of high-density lipoprotein (HDL) to promote cellular cholesterol efflux is a more robust predictor of cardiovascular disease protection than HDL-cholesterol levels in plasma. Previously, we found that lipidated...
2.
Jerome W, Hart R, Aller S, Tang C, Heinecke J, Davidson W, et al.
Microsc Microanal
. 2024 Oct;
29(29 Suppl 1):1096-1097.
PMID: 39479567
No abstract available.
3.
He Y, Pavanello C, Hutchins P, Tang C, Pourmousa M, Vaisar T, et al.
Circulation
. 2023 Nov;
149(10):774-787.
PMID: 38018436
Background: Cholesterol efflux capacity (CEC) predicts cardiovascular disease independently of high-density lipoprotein (HDL) cholesterol levels. Isolated small HDL particles are potent promoters of macrophage CEC by the ABCA1 (ATP-binding cassette...
4.
He Y, Pavanello C, Hutchins P, Tang C, Pourmousa M, Vaisar T, et al.
medRxiv
. 2023 Nov;
PMID: 37961344
Background: Cholesterol efflux capacity (CEC) predicts cardiovascular disease (CVD) independently of HDL cholesterol (HDL-C) levels. Isolated small HDL particles are potent promoters of macrophage CEC by the ABCA1 pathway, but...
5.
Segrest J, Davidson W, Heinecke J
Curr Opin Lipidol
. 2023 Aug;
34(5):208-213.
PMID: 37548415
Purpose Of Review: ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) biogenesis and cholesterol export from artery wall cells. Recent evidence challenges the generally accepted...
6.
Segrest J, Tang C, Song H, Jones M, Davidson W, Aller S, et al.
Nat Commun
. 2022 Aug;
13(1):4812.
PMID: 35974019
Production of high density lipoprotein (HDL) requires ATP-binding cassette transporter A1 (ABCA1) to drive phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I. Here, we use simulations to show...
7.
Aller S, Segrest J
PLoS One
. 2022 Feb;
17(2):e0262746.
PMID: 35120130
ABCA1 and ABCA4 are enigmatic because they transport substrates in opposite directions yet share >50% amino acid identity. ABCA4 imports lipid conjugates but ABCA1 exports lipids. Both hydrolyze ATP to...
8.
Bedi S, Morris J, Shah A, Hart R, Jerome W, Aller S, et al.
J Lipid Res
. 2022 Jan;
63(3):100168.
PMID: 35051413
Because of its critical role in HDL formation, significant efforts have been devoted to studying apolipoprotein A-I (APOA1) structural transitions in response to lipid binding. To assess the requirements for...
9.
Melchior J, Street S, Vaisar T, Hart R, Jerome J, Kuklenyik Z, et al.
J Lipid Res
. 2021 Jul;
62:100099.
PMID: 34324889
Human high-density lipoproteins (HDLs) are a complex mixture of structurally related nanoparticles that perform distinct physiological functions. We previously showed that human HDL containing apolipoprotein A-I (APOA1) but not apolipoprotein...
10.
Albertolle M, Song H, Wilkey C, Segrest J, Guengerich F
Chem Res Toxicol
. 2021 Jan;
34(3):930.
PMID: 33475339
No abstract available.