Jens Soltwisch
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Explore the profile of Jens Soltwisch including associated specialties, affiliations and a list of published articles.
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52
Citations
626
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Recent Articles
1.
Spangenberg P, Bessler S, Widera L, Bottek J, Richter M, Thiebes S, et al.
Nat Commun
. 2025 Jan;
16(1):1065.
PMID: 39870624
Multimodal imaging by matrix-assisted laser desorption ionisation mass spectrometry imaging (MALDI MSI) and microscopy holds potential for understanding pathological mechanisms by mapping molecular signatures from the tissue microenvironment to specific...
2.
Schwenzfeier J, Weischer S, Bessler S, Soltwisch J
J Am Soc Mass Spectrom
. 2024 Oct;
35(12):2950-2959.
PMID: 39383330
We introduce Fluorescence Integrated Single-Cell Analysis Script (FISCAS), which combines fluorescence microscopy with MALDI-MSI to streamline single-cell analysis. FISCAS enables automated selection of tight measurement regions, thereby reducing the acquisition...
3.
Muller W, Potthoff A, Dreisewerd K, Soltwisch J
Rapid Commun Mass Spectrom
. 2024 Aug;
:e9895.
PMID: 39215964
Rationale: Surface-assisted laser desorption/ionization (SALDI) mass spectrometry (MS) builds on the use of nanostructured surfaces (e.g., coatings of colloidal nanoparticles) to promote analyte desorption and ionization. The SALDI process is...
4.
Soltwisch J, Palmer A, Hong H, Majer J, Dreisewerd K, Marshall P
Anal Chem
. 2024 Jun;
96(25):10294-10301.
PMID: 38864171
The successful application of matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) in pharmaceutical research is strongly dependent on the detection of the drug of interest at physiologically relevant concentrations....
5.
Bourceau P, Geier B, Suerdieck V, Bien T, Soltwisch J, Dreisewerd K, et al.
Nat Protoc
. 2023 Sep;
18(10):3050-3079.
PMID: 37674095
Label-free molecular imaging techniques such as matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) enable the direct and simultaneous mapping of hundreds of different metabolites in thin sections of biological...
6.
Hoffmann E, Schache D, Holtke C, Soltwisch J, Niland S, Krahling T, et al.
J Transl Med
. 2023 Aug;
21(1):577.
PMID: 37641066
Background: With metabolic alterations of the tumor microenvironment (TME) contributing to cancer progression, metastatic spread and response to targeted therapies, non-invasive and repetitive imaging of tumor metabolism is of major...
7.
Bessler S, Soltwisch J, Dreisewerd K
Anal Chem
. 2023 Jul;
95(30):11352-11358.
PMID: 37458700
The precise fatty acyl chain configuration of cardiolipin (CL), a tetrameric mitochondrial-specific membrane lipid, exhibits dependence on cell and tissue types. A powerful method to map CL profiles in tissue...
8.
Soltwisch J, Heijs B
Methods Mol Biol
. 2023 Jul;
2688:173-186.
PMID: 37410293
Matrix-assisted laser desorption/ionization mass spectrometry imaging with laser-induced postionization (MALDI-2-MSI) has proven a powerful tool for the in situ analysis of N-linked glycosylation, or N-glycans, directly from clinical tissue samples....
9.
Bien T, Koerfer K, Schwenzfeier J, Dreisewerd K, Soltwisch J
Proc Natl Acad Sci U S A
. 2022 Jul;
119(29):e2114365119.
PMID: 35858333
Molecular analysis on the single-cell level represents a rapidly growing field in the life sciences. While bulk analysis from a pool of cells provides a general molecular profile, it is...
10.
Bookmeyer C, Rohling U, Dreisewerd K, Soltwisch J
Angew Chem Int Ed Engl
. 2022 Jun;
61(34):e202202165.
PMID: 35727295
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a rapidly growing method in the life sciences. However, for many analyte classes, its sensitivity is limited due to poor ionization efficiencies....