Jens Peter von Kries
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Explore the profile of Jens Peter von Kries including associated specialties, affiliations and a list of published articles.
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55
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1386
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Recent Articles
11.
Aguirre T, Dornan G, Hostachy S, Neuenschwander M, Seyffarth C, Haucke V, et al.
Elife
. 2023 Oct;
12.
PMID: 37843983
Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function. While the development of potent IP6K inhibitors is...
12.
Kucukdisli M, Bel-Abed H, Cirillo D, Lo W, Efrem N, Horatscheck A, et al.
J Med Chem
. 2023 Oct;
66(20):14278-14302.
PMID: 37819647
Class II phosphoinositide-3-kinases (PI3Ks) play central roles in cell signaling, division, migration, and survival. Despite evidence that all PI3K class II isoforms serve unique cellular functions, the lack of isoform-selective...
13.
Lopez J, Dornan G, Boback N, Neuenschwander M, Oder A, Kemnitz-Hassanin K, et al.
Chembiochem
. 2023 Sep;
24(24):e202300555.
PMID: 37769151
Uridine diphosphate N-acetylglucosamine 2-epimerase (GNE) is a key enzyme in the sialic acid biosynthesis pathway. Sialic acids are primarily terminal carbohydrates on glycans and play fundamental roles in health and...
14.
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors
Mucka P, Lindemann P, Bosco B, Willenbrock M, Radetzki S, Neuenschwander M, et al.
Cell Chem Biol
. 2023 Jul;
30(10):1303-1312.e3.
PMID: 37506701
Transcription factor NF-κB potently activates anti-apoptotic genes, and its inactivation significantly reduces tumor cell survival following genotoxic stresses. We identified two structurally distinct lead compounds that selectively inhibit NF-κB activation...
15.
Mehboob R, von Kries J, Ehsan K, Almansouri M, Bamaga A
Front Neurol
. 2023 Jul;
14:1210194.
PMID: 37456637
Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) causes coronavirus disease 2019 (COVID-19), which became a pandemic in late 2019 and early 2020. Apart from many other symptoms of this...
16.
Renikunta H, Lazarow K, Gong Y, Shukla P, Nageswaran V, Giral H, et al.
iScience
. 2023 May;
26(5):106593.
PMID: 37250320
Ischemic cardiomyopathy, driven by loss of cardiomyocytes and inadequate proliferative response, persists to be a major global health problem. Using a functional high-throughput screening, we assessed differential proliferative potential of...
17.
Jordan P, Costa A, Specker E, Popp O, Volkamer A, Piske R, et al.
PLoS One
. 2023 Feb;
18(2):e0278325.
PMID: 36745631
Microglia are the immune effector cells of the central nervous system (CNS) and react to pathologic events with a complex process including the release of nitric oxide (NO). NO is...
18.
Jeanclos E, Schlotzer J, Hadamek K, Yuan-Chen N, Alwahsh M, Hollmann R, et al.
Nat Commun
. 2022 Nov;
13(1):6845.
PMID: 36369173
Targeting the intrinsic metabolism of immune or tumor cells is a therapeutic strategy in autoimmunity, chronic inflammation or cancer. Metabolite repair enzymes may represent an alternative target class for selective...
19.
TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation
Tufan A, Lazarow K, Kolesnichenko M, Sporbert A, von Kries J, Scheidereit C
EMBO J
. 2022 Sep;
41(21):e110372.
PMID: 36124865
In a genome-wide screening for components of the dsDNA-break-induced IKK-NF-κB pathway, we identified scores of regulators, including tumor susceptibility gene TSG101. TSG101 is essential for DNA damage-induced formation of cellular...
20.
Lo W, Belabed H, Kucukdisli M, Metag J, Roske Y, Prokofeva P, et al.
Nat Chem Biol
. 2022 Sep;
19(1):18-27.
PMID: 36109648
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis,...