Martin Neuenschwander
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Explore the profile of Martin Neuenschwander including associated specialties, affiliations and a list of published articles.
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Citations
846
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Recent Articles
1.
Mohd S, Oder A, Specker E, Neuenschwander M, von Kries J, Daumke O
PLoS One
. 2024 Jul;
19(7):e0302704.
PMID: 39074100
Eps15 (epidermal growth factor receptor pathway substrate 15) homology domain-containing proteins (EHDs) comprise a family of eukaryotic dynamin-related ATPases that participate in various endocytic membrane trafficking pathways. Dysregulation of EHDs...
2.
Brenner M, Zink C, Witzinger L, Keller A, Hadamek K, Bothe S, et al.
Elife
. 2024 Jun;
13.
PMID: 38856179
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether...
3.
Aguirre T, Dornan G, Hostachy S, Neuenschwander M, Seyffarth C, Haucke V, et al.
Elife
. 2023 Oct;
12.
PMID: 37843983
Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function. While the development of potent IP6K inhibitors is...
4.
Kucukdisli M, Bel-Abed H, Cirillo D, Lo W, Efrem N, Horatscheck A, et al.
J Med Chem
. 2023 Oct;
66(20):14278-14302.
PMID: 37819647
Class II phosphoinositide-3-kinases (PI3Ks) play central roles in cell signaling, division, migration, and survival. Despite evidence that all PI3K class II isoforms serve unique cellular functions, the lack of isoform-selective...
5.
Lopez J, Dornan G, Boback N, Neuenschwander M, Oder A, Kemnitz-Hassanin K, et al.
Chembiochem
. 2023 Sep;
24(24):e202300555.
PMID: 37769151
Uridine diphosphate N-acetylglucosamine 2-epimerase (GNE) is a key enzyme in the sialic acid biosynthesis pathway. Sialic acids are primarily terminal carbohydrates on glycans and play fundamental roles in health and...
6.
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors
Mucka P, Lindemann P, Bosco B, Willenbrock M, Radetzki S, Neuenschwander M, et al.
Cell Chem Biol
. 2023 Jul;
30(10):1303-1312.e3.
PMID: 37506701
Transcription factor NF-κB potently activates anti-apoptotic genes, and its inactivation significantly reduces tumor cell survival following genotoxic stresses. We identified two structurally distinct lead compounds that selectively inhibit NF-κB activation...
7.
Ahmed S, Ragunathan P, Shin J, Peter S, Kleissle S, Neuenschwander M, et al.
FEBS Lett
. 2023 Jun;
597(15):1977-1988.
PMID: 37259564
The architectural chromatin factor high-mobility group AT-hook 2 (HMGA2) is causally involved in several human malignancies and pathologies. HMGA2 is not expressed in most normal adult somatic cells, which renders...
8.
Jordan P, Costa A, Specker E, Popp O, Volkamer A, Piske R, et al.
PLoS One
. 2023 Feb;
18(2):e0278325.
PMID: 36745631
Microglia are the immune effector cells of the central nervous system (CNS) and react to pathologic events with a complex process including the release of nitric oxide (NO). NO is...
9.
Jeanclos E, Schlotzer J, Hadamek K, Yuan-Chen N, Alwahsh M, Hollmann R, et al.
Nat Commun
. 2022 Nov;
13(1):6845.
PMID: 36369173
Targeting the intrinsic metabolism of immune or tumor cells is a therapeutic strategy in autoimmunity, chronic inflammation or cancer. Metabolite repair enzymes may represent an alternative target class for selective...
10.
Lo W, Belabed H, Kucukdisli M, Metag J, Roske Y, Prokofeva P, et al.
Nat Chem Biol
. 2022 Sep;
19(1):18-27.
PMID: 36109648
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis,...