Jeffrey S Moffit
Overview
Explore the profile of Jeffrey S Moffit including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
172
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Plasschaert L, MacDonald K, Moffit J
Front Pharmacol
. 2024 Oct;
15:1476331.
PMID: 39439894
Cystic fibrosis is a life-threatening disease that is caused by mutations in , a gene which encodes an ion channel that supports proper function of several epithelial tissues, most critically...
2.
Moffit J, Blanset D, Lynch J, MacLachlan T, Meyer K, Ponce R, et al.
Hum Gene Ther
. 2022 Aug;
33(21-22):1126-1141.
PMID: 35994386
The nonclinical safety assessments for gene therapies are evolving, leveraging over 20 years of experimental and clinical experience. Despite the growing experience with these therapeutics, there are no approved harmonized...
3.
Bursavich M, Harrison B, Acharya R, Costa D, Freeman E, Hrdlicka L, et al.
J Med Chem
. 2021 Sep;
64(19):14426-14447.
PMID: 34550687
The recent approval of aducanumab for Alzheimer's disease has heightened the interest in therapies targeting the amyloid hypothesis. Our research has focused on identification of novel compounds to improve amyloid...
4.
Bursavich M, Harrison B, Acharya R, Costa D, Freeman E, Hodgdon H, et al.
J Med Chem
. 2017 Feb;
60(6):2383-2400.
PMID: 28230986
Herein we describe the design, synthesis, and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conformational restriction. Oxadiazine lead...
5.
Dere E, Spade D, Hall S, Altemus A, Smith J, Phillips J, et al.
Toxicol Appl Pharmacol
. 2017 Feb;
320:1-7.
PMID: 28167222
The human testis is sensitive to toxicant-induced injury but current methods for detecting adverse effects are limited, insensitive and unreliable. Animal studies use sensitive histopathological endpoints to assess toxicity, but...
6.
Moffit J, Her L, Mineo A, Knight B, Phillips J, Thibodeau M
Birth Defects Res B Dev Reprod Toxicol
. 2013 Feb;
98(1):17-28.
PMID: 23364888
Although histopathology is considered the gold standard for assessing testicular toxicity in the nonclinical setting, identification of noninvasive biomarkers for testicular injury are desirable to improve safety monitoring capabilities for...
7.
Chapin R, Weinbauer G, Thibodeau M, Sonee M, Saldutti L, Reagan W, et al.
Birth Defects Res B Dev Reprod Toxicol
. 2013 Feb;
98(1):110-8.
PMID: 23364877
The Developmental and Reproductive Toxicity Technical Committee of the Health and Environmental Sciences Institute hosted a working consortium of companies to evaluate a new commercially available analytic assay for Inhibin...
8.
Moffit J, Bryant B, Hall S, Boekelheide K
Toxicol Pathol
. 2007 Sep;
35(5):719-27.
PMID: 17763286
Sertoli cells are the primary cellular target for a number of pharmaceutical and environmental testicular toxicants, including 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate. Exposure to these individual compounds can result in...
9.
Klysik J, Theroux S, Sedivy J, Moffit J, Boekelheide K
Cell Signal
. 2007 Aug;
20(1):1-9.
PMID: 17706925
The Raf kinase inhibitory protein 1 (RKIP-1) and its orthologs are conserved throughout evolution and widely expressed in eukaryotic organisms. In its non-phosphorylated form RKIP-1 negatively regulates the Raf/MEK/ERK pathway...
10.
Moffit J, Koza-Taylor P, Holland R, Thibodeau M, Beger R, Lawton M, et al.
Toxicol Appl Pharmacol
. 2007 Jun;
222(2):169-79.
PMID: 17585979
Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity. Previous studies have shown that activation of the nuclear peroxisome proliferator activated receptor-alpha (PPARalpha) is required...