Jeffrey R Leipprandt
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Explore the profile of Jeffrey R Leipprandt including associated specialties, affiliations and a list of published articles.
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11
Citations
180
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Recent Articles
1.
Roy A, Leipprandt J, Patterson J, Stoll A, Kemp C, Oula Z, et al.
J Pharmacol Exp Ther
. 2024 Jun;
390(2):250-259.
PMID: 38866563
Mutations in the gene, which encodes the abundant brain G-protein G , result in neurologic disorders characterized by developmental delay, epilepsy, and movement abnormalities. There are over 50 mutant alleles...
2.
Omouessi S, Leipprandt J, Akoume M, Charbeneau R, Wade S, Neubig R
Mol Cell Endocrinol
. 2020 Dec;
521:111098.
PMID: 33278490
Mice carrying an RGS-insensitive Gαi2 mutation display growth retardation early after birth. Although the growth hormone (GH)-axis is a key endocrine modulator of postnatal growth, its functional state in these...
3.
Larrivee C, Feng H, Quinn J, Shaw V, Leipprandt J, Demireva E, et al.
J Pharmacol Exp Ther
. 2020 Jan;
373(1):24-33.
PMID: 31907305
Neurodevelopmental disorder with involuntary movements (Online Mendelian Inheritance in Man: 617493) is a severe, early onset neurologic condition characterized by a delay in psychomotor development, hypotonia, and hyperkinetic involuntary movements....
4.
Kahl D, Hutchings K, Lisabeth E, Haak A, Leipprandt J, Dexheimer T, et al.
J Med Chem
. 2019 Apr;
62(9):4350-4369.
PMID: 30951312
Through a phenotypic high-throughput screen using a serum response element luciferase promoter, we identified a novel 5-aryl-1,3,4-oxadiazol-2-ylthiopropionic acid lead inhibitor of Rho/myocardin-related transcription factor (MRTF)/serum response factor (SRF)-mediated gene transcription...
5.
Hutchings K, Lisabeth E, Rajeswaran W, Wilson M, Sorenson R, Campbell P, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(8):1744-1749.
PMID: 28285914
We recently reported the development of a novel inhibitor of Rho-mediated gene transcription (1, CCG-203971) that is efficacious in multiple animal models of acute fibrosis, including scleroderma, when given intraperitoneally....
6.
Aupperlee M, Zhao Y, Tan Y, Leipprandt J, Bennett J, Haslam S, et al.
Endocrinology
. 2014 Apr;
155(6):2301-13.
PMID: 24693965
It is well documented that macrophages and eosinophils play important roles in normal murine pubertal mammary gland development. Although it is accepted that estrogen (E) and progesterone (P) are key...
7.
Aupperlee M, Leipprandt J, Bennett J, Schwartz R, Haslam S
Breast Cancer Res
. 2013 May;
15(3):R44.
PMID: 23705924
Introduction: Puberty is a period of increased susceptibility to factors that cause increased breast cancer risk in adulthood. Mammary end buds (EBs) that develop during puberty are believed to be...
8.
Kariagina A, Xie J, Leipprandt J, Haslam S
Horm Cancer
. 2011 Jan;
1(5):229-44.
PMID: 21258428
Both estrogen (E) and progesterone (P) are implicated in the etiology of human breast cancer. Defining their mechanisms of action, particularly in vivo, is relevant to the prevention and therapy...
9.
Santos S, Aupperlee M, Xie J, Durairaj S, Miksicek R, Conrad S, et al.
J Steroid Biochem Mol Biol
. 2009 Apr;
115(3-5):161-72.
PMID: 19383543
Progesterone, through the progesterone receptor (PR), promotes development of the normal mammary gland and is implicated in the etiology of breast cancer. We identified PRA-regulated genes by microarray analysis of...
10.
Mirafzali Z, Leipprandt J, McCracken J, DeWitt D
J Biol Chem
. 2006 Jul;
281(38):28354-64.
PMID: 16809339
The topology of association of the monotopic protein cyclooxygenase-2 (COX-2) with membranes has been examined using EPR spectroscopy of spin-labeled recombinant human COX-2. Twenty-four mutants, each containing a single free...