Jeffrey R Jacobson
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Explore the profile of Jeffrey R Jacobson including associated specialties, affiliations and a list of published articles.
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72
Citations
3359
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Recent Articles
1.
Chen W, Epshtein Y, Vagts C, Cress A, Jacobson J
Int J Mol Sci
. 2025 Mar;
26(5).
PMID: 40076507
Integrin β4 (ITGB4) mediates lung endothelial cell (EC) inflammation attenuated by simvastatin, an HMG CoA-reductase inhibitor. The cytoplasmic domain of ITGB4 is predicted to bind kindlin-2. Kindlin-2 expression is mediated...
2.
Ha A, Meliton L, Chen W, Wang L, Maienschein-Cline M, Jacobson J, et al.
FASEB J
. 2024 Nov;
38(22):e70205.
PMID: 39588951
Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of severe pneumonia and acute respiratory distress syndrome (ARDS). To advance our mechanistic understanding of this important pathogen, we characterized the effects...
3.
Tang H, Gupta A, Morrisroe S, Bao C, Schwantes-An T, Gupta G, et al.
Circulation
. 2024 May;
150(4):302-316.
PMID: 38695173
Background: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin...
4.
Zeng Z, Abdelwahid E, Chen W, Ascoli C, Pham T, Jacobson J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 Apr;
326(6):L687-L697.
PMID: 38563965
Chronic cigarette smoke exposure decreases lung expression of which is known to protect the endothelial barrier during infectious models of acute respiratory distress syndrome (ARDS). Proteomic analysis of -silenced endothelial...
5.
Epshtein Y, Mathew B, Chen W, Jacobson J
Cells
. 2023 Oct;
12(19).
PMID: 37830619
GADD45a is a gene we previously reported as a mediator of responses to acute lung injury. GADD45a-/- mice express decreased Akt and increased Akt ubiquitination due to the reduced expression...
6.
Anis M, Gonzales J, Halstrom R, Baig N, Humpal C, Demeritte R, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362426
Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction, uncontrolled proliferation and migration of pulmonary arterial endothelial cells leading to increased pulmonary vascular resistance resulting in great morbidity and poor...
7.
Mascarenhas J, Song J, A Gaber A, Jacobson J, Cress A, Camp S, et al.
Cell Physiol Biochem
. 2022 Jul;
56(4):329-339.
PMID: 35856787
Background/aims: Increase in vascular permeability is a cardinal feature of all inflammatory diseases and represents an imbalance in vascular contractile forces and barrier-restorative forces, both of which are highly dependent...
8.
Bhattacharya J, Booy R, Casadevall A, Dela Cruz C, Fedson D, Garcia J, et al.
Pharmacol Res Perspect
. 2022 Jul;
10(4):e00988.
PMID: 35837790
No abstract available.
9.
Sammani S, Bermudez T, Kempf C, Song J, Fleming J, Reyes Hernon V, et al.
Front Physiol
. 2022 Jul;
13:916159.
PMID: 35812318
Numerous potential ARDS therapeutics, based upon preclinical successful rodent studies that utilized LPS challenge without mechanical ventilation, have failed in Phase 2/3 clinical trials. Recently, ALT-100 mAb, a novel biologic...
10.
Chen W, Gard J, Epshtein Y, Camp S, Garcia J, Jacobson J, et al.
Front Physiol
. 2022 Mar;
13:769325.
PMID: 35250607
We previously reported integrin beta 4 (ITGB4) is an important mediator of lung vascular protection by simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A-reductase inhibitor. In this study, we report increased endothelial cell (EC)...