Jeffrey N Savas
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Explore the profile of Jeffrey N Savas including associated specialties, affiliations and a list of published articles.
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103
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5071
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Recent Articles
1.
Paumier J, Zewe J, Panja C, Pergande M, Venkatesan M, Israeli E, et al.
JCI Insight
. 2025 Mar;
10(5).
PMID: 40059823
Neurofilament accumulation is associated with many neurodegenerative diseases, but it is the primary pathology in giant axonal neuropathy (GAN). This childhood-onset autosomal recessive disease is caused by loss-of-function mutations in...
2.
Telenson A, Hsieh R, Cowen G, Sode E, Kwon J, Vo A, et al.
FASEB J
. 2025 Mar;
39(5):e70423.
PMID: 40022605
Spontaneous mouse mutants have helped define genetic contributions to many phenotypes. Here we report a spontaneous Novel Ataxic Phenotype in mice. Ataxia findings were evident at post-natal day 11 in...
3.
Wood J, Dulewicz M, Wood J, Ge J, Stringer K, Szadziewska A, et al.
Res Sq
. 2025 Feb;
PMID: 39975899
Understanding how amyloid beta (Aβ) plaques form and progress to neurotoxicity in Alzheimer's disease remains a significant challenge. This study aims to elucidate the processes involved in Aβ plaque formation...
4.
Joshi Y, Savas J
J Clin Invest
. 2025 Feb;
135(3).
PMID: 39895634
Sensorineural hearing loss (SNHL) is the most prevalent form of permanent hearing impairment, arising from factors such as aging, exposure to loud noise, disease, ototoxic medications, and genetic mutations. Despite...
5.
6.
Coy-Dibley J, Jayaraj N, Ren D, Pacifico P, Belmadani A, Wang Y, et al.
Neurobiol Pain
. 2025 Jan;
17:100176.
PMID: 39811188
Painful diabetic neuropathy (PDN) is a challenging complication of diabetes with patients experiencing a painful and burning sensation in their extremities. Existing treatments provide limited relief without addressing the underlying...
7.
Khalatyan N, Cornish D, Ferrell A, Savas J, Shen P, Hultquist J, et al.
Cell Rep
. 2025 Jan;
44(1):115119.
PMID: 39786991
Growing evidence suggests that ribosomes selectively regulate translation of specific mRNA subsets. Here, quantitative proteomics and cryoelectron microscopy demonstrate that poxvirus infection does not alter ribosomal subunit protein (RP) composition...
8.
Dos Santos M, Forrest M, Bomba-Warczak E, Parnell E, Edassery S, Yang K, et al.
bioRxiv
. 2025 Jan;
PMID: 39763806
Neuronal connection dysfunction is a convergent cause of cognitive deficits in mental disorders. Cognitive processes are finely regulated at the synaptic level by membrane proteins, some of which are shed...
9.
Fleming A, Rao N, Wright M, Savas J, Kiskinis E
bioRxiv
. 2024 Dec;
PMID: 39651147
The degeneration of neurons in patients with amyotrophic lateral sclerosis (ALS) is commonly associated with accumulation of misfolded, insoluble proteins. Heat shock proteins (HSPs) are central regulators of protein homeostasis...
10.
Rao N, DeGulis O, Nomura T, Lee S, Hark T, Dynes J, et al.
bioRxiv
. 2024 Nov;
PMID: 39554163
In Alzheimer's disease (AD), amyloid-beta (Aβ) peptides are produced by proteolytic cleavage of the amyloid precursor protein (APP), which can occur during synaptic vesicle (SV) cycling at presynapses. Precisely how...