Jeffrey N Joyce
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Explore the profile of Jeffrey N Joyce including associated specialties, affiliations and a list of published articles.
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22
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Recent Articles
1.
Wills J, Jones J, Haggerty T, Duka V, Joyce J, Sidhu A
Exp Neurol
. 2010 Jul;
225(1):210-8.
PMID: 20599975
Parkinson's disease (PD), a progressive neurodegenerative disease, results in abnormal accumulation of insoluble alpha-synuclein (alpha-Syn) in dopaminergic neurons. Here we examined tauopathic changes and the alpha-Syn/p-GSK-3beta/proteasome pathway in postmortem striata...
2.
Massa S, Yang T, Xie Y, Shi J, Bilgen M, Joyce J, et al.
J Clin Invest
. 2010 Apr;
120(5):1774-85.
PMID: 20407211
Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function. Correlations between altered BDNF expression and/or function...
3.
Iarkov A, Der T, Joyce J
Eur J Pharmacol
. 2009 Nov;
627(1-3):177-84.
PMID: 19909735
It is not known if age plays an important role in the D(3) receptor regulation of N-methyl-D-aspartate (NMDA) receptor antagonist induced hyperactivity. Wild type (WT) and dopamine D(3) receptor mutant...
4.
Yarkov A, Der T, Joyce J
Eur J Pharmacol
. 2009 Nov;
627(1-3):167-72.
PMID: 19900441
There are contradictory data regarding the role of the dopamine D(3) receptor in regulating N-methyl-d-aspartate (NMDA) receptor antagonist (e.g., dizocilpine) induced hyperactivity. The purpose of the present study was to...
5.
Kufahl P, Zavala A, Singh A, Thiel K, Dickey E, Joyce J, et al.
Synapse
. 2009 Jun;
63(10):823-35.
PMID: 19533625
The capability of cocaine cues to generate craving in cocaine-dependent humans, even after extended abstinence, is modeled in rats using cue reinstatement of extinguished cocaine-seeking behavior. We investigated neural activity...
6.
Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models
Duka T, Duka V, Joyce J, Sidhu A
FASEB J
. 2009 Apr;
23(9):2820-30.
PMID: 19369384
We have shown in the parkinsonism-inducing neurotoxin MPP(+)/MPTP model that alpha-Synuclein (alpha-Syn), a presynaptic protein causal in Parkinson's disease (PD), contributes to hyperphosphorylation of Tau (p-Tau), a protein normally linked...
7.
Zavala A, Osredkar T, Joyce J, Neisewander J
Synapse
. 2008 Mar;
62(6):421-31.
PMID: 18361437
Cocaine-associated cues acquire incentive motivational effects that manifest as cue-elicited craving in humans and cocaine-seeking behavior in rats. Here we examine the hypothesis that neuronal processes associated with incentive motivational...
8.
Mastroeni D, Grover A, Leonard B, Joyce J, Coleman P, Kozik B, et al.
Neurobiol Aging
. 2008 Mar;
30(11):1805-17.
PMID: 18325635
Activated microglia appear to selectively attack dopamine (DA) neurons in the Parkinson's disease (PD) substantia nigra. We investigated potential mechanisms using culture models. As targets, human SH-SY5Y cells were left...
9.
Joyce J, Millan M
Curr Opin Pharmacol
. 2006 Dec;
7(1):100-5.
PMID: 17174156
Parkinson's disease is a severe, age-related neurodegenerative disorder in which a loss of substantia nigra-derived dopaminergic pathways to the striatum triggers profound motor perturbation, as well as cognitive, sensory and...
10.
Joyce J, Millan M
Drug Discov Today
. 2005 Jul;
10(13):917-25.
PMID: 15993811
The behavioral and pathophysiological role of the dopamine D(3) receptor, which was deduced from anatomical, lesion and drug treatment studies in the ten years following cloning of the receptor, indicated...