Jeffrey K Kerns
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Explore the profile of Jeffrey K Kerns including associated specialties, affiliations and a list of published articles.
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16
Citations
365
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Recent Articles
11.
Smith A, Lin Q, Doughty V, Zhuang L, McBriar M, Kerns J, et al.
Tetrahedron
. 2010 Feb;
65(33):6470-6488.
PMID: 20161196
Evolution of a convergent synthetic strategy to access (+)-spongistatin 2 (2), a potent cytotoxic marine macrolide, is described. Highlights of the synthesis include: development of a multicomponent dithiane-mediated linchpin union...
12.
Bamborough P, Callahan J, Christopher J, Kerns J, Liddle J, Miller D, et al.
Curr Top Med Chem
. 2009 Aug;
9(7):623-39.
PMID: 19689370
The IkappaB kinases (IKKs) are essential components of the signaling pathway by which the NF-kappaB p50/RelA transcription factor is activated in response to pro-inflammatory stimuli such as lipopolysaccharide (LPS) and...
13.
Christopher J, Bamborough P, Alder C, Campbell A, Cutler G, Down K, et al.
J Med Chem
. 2009 Apr;
52(9):3098-102.
PMID: 19348415
The identification and progression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described. Hit-generation chemistry based on IKK-beta active-site knowledge yielded a weakly potent...
14.
Wang Y, Busch-Petersen J, Wang F, Ma L, Fu W, Kerns J, et al.
Bioorg Med Chem Lett
. 2007 May;
17(14):3864-7.
PMID: 17524641
A series of 3-arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides were prepared and shown to be novel and selective antagonists of the CXCR2 receptor. Synthesis, structure and activity relationships, selectivity, and some developability properties are...
15.
Christopher J, Avitabile B, Bamborough P, Champigny A, Cutler G, Dyos S, et al.
Bioorg Med Chem Lett
. 2007 May;
17(14):3972-7.
PMID: 17502144
A potent and selective series of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta is described. The most potent compounds are 8h, 8r and 8v, with IKK-beta inhibitory potencies of pIC(50) 7.0,...
16.
Smith Iii A, Lin Q, Doughty V, Zhuang L, McBriar M, Kerns J, et al.
Angew Chem Int Ed Engl
. 2001 Feb;
40(1):196-199.
PMID: 11169711
No abstract available.