David D Miller
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Explore the profile of David D Miller including associated specialties, affiliations and a list of published articles.
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16
Citations
61
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Recent Articles
1.
Johnson C, Miller D, Bianchi L
MicroPubl Biol
. 2021 Jun;
2021.
PMID: 34189421
MEC-4 and UNC-8 belong to the DEG/ENaC family of voltage-independent Na channels and have been implicated in mechanosensation and synaptic remodeling. MEC-4 and UNC-8 hyperactive mutants, designated (d) mutants, conduct...
2.
Kerns J, Busch-Petersen J, Fu W, Boehm J, Nie H, Muratore M, et al.
ACS Med Chem Lett
. 2019 Jan;
9(12):1164-1169.
PMID: 30613320
IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization...
3.
Tucker J, Adamson G, Ferguson J, Garrett-Davis J, Goldstein E, Hlebinsky A, et al.
Technol Cult
. 2018 Sep;
59(3):719-769.
PMID: 30245500
No abstract available.
4.
Davies D, Crowe M, Lucas N, Quinn J, Miller D, Pritchard S, et al.
Bioorg Med Chem Lett
. 2012 Feb;
22(7):2620-3.
PMID: 22366657
A series of novel benzimidazoles are discussed as NR2B-selective N-methyl-d-aspartate (NMDA) receptor antagonists. High throughput screening (HTS) efforts identified a number of potent and selective NR2B antagonists such as 1....
5.
Miller D, Bamborough P, Christopher J, Baldwin I, Champigny A, Cutler G, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(8):2255-8.
PMID: 21429745
The discovery and hit-to-lead exploration of a novel series of selective IKK-β kinase inhibitors is described. The initial lead fragment 3 was identified by pharmacophore-directed virtual screening. Homology model-driven SAR...
6.
Down K, Bamborough P, Alder C, Campbell A, Christopher J, Gerelle M, et al.
Bioorg Med Chem Lett
. 2010 Jun;
20(13):3936-40.
PMID: 20570148
A novel pyrrole-2-carboxamide series of p38alpha inhibitors, discovered through the application of virtual screening, is presented. Following evaluation of activity, selectivity and developability properties of commercially available analogues, a synthesis...
7.
Pattison G, Sandford G, Yufit D, Howard J, Christopher J, Miller D
Beilstein J Org Chem
. 2010 Jun;
6:45.
PMID: 20563272
Reaction of tetrafluoropyridazine with catechol gives a tricyclic 9,10-dioxa-1,2-diaza-anthracene system by a sequential nucleophilic aromatic substitution ring annelation process, further extending the use of perfluoroheteroaromatic derivatives for the synthesis of...
8.
Kupas D, Miller D
Prehosp Emerg Care
. 2010 Apr;
14(3):349-54.
PMID: 20397867
Initial care for the burned trauma patient focuses on the rapid assessment and stabilization of airway, breathing, and circulation. Circumferential chest burns may restrict respiratory effort and inhibit adequate ventilation....
9.
Bamborough P, Callahan J, Christopher J, Kerns J, Liddle J, Miller D, et al.
Curr Top Med Chem
. 2009 Aug;
9(7):623-39.
PMID: 19689370
The IkappaB kinases (IKKs) are essential components of the signaling pathway by which the NF-kappaB p50/RelA transcription factor is activated in response to pro-inflammatory stimuli such as lipopolysaccharide (LPS) and...
10.
Pattison G, Sandford G, Yufit D, Howard J, Christopher J, Miller D
J Org Chem
. 2009 Jun;
74(15):5533-40.
PMID: 19518071
4,5,6-trifluoropyridazin-3(2H)-one can be used as a scaffold for the synthesis of various 4,5- and 4,6-disubstituted and ring-fused pyridazinone systems by sequential nucleophilic aromatic substitution processes. Although the regioselectivity of nucleophilic...