Jeffrey J Clare
Overview
Explore the profile of Jeffrey J Clare including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
422
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Recent Articles
1.
Qiao X, Sun G, Clare J, Werkman T, Wadman W
Br J Pharmacol
. 2013 Nov;
171(4):1054-67.
PMID: 24283699
Background And Purpose: Voltage-activated Na(+) channels contain one distinct α-subunit. In the brain NaV 1.1, NaV 1.2, NaV 1.3 and NaV 1.6 are the four most abundantly expressed α-subunits. The...
2.
Yereddi N, Cusdin F, Namadurai S, Packman L, Monie T, Slavny P, et al.
FASEB J
. 2012 Nov;
27(2):568-80.
PMID: 23118027
The β subunits of voltage-gated sodium (Na(v)) channels possess an extracellular immunoglobulin (Ig) domain that is related to the L1 family of cell-adhesion molecules (CAMs). Here we show that in...
3.
Gaudioso C, Carlier E, Youssouf F, Clare J, Debanne D, Alcaraz G
Biochem Biophys Res Commun
. 2011 Jul;
411(2):329-34.
PMID: 21726526
Mutations in the neuronal Nav1.1 voltage-gated sodium channel are responsible for mild to severe epileptic syndromes. The ubiquitous calcium sensor calmodulin (CaM) bound to rat brain Nav1.1 and to the...
4.
Cusdin F, Nietlispach D, Maman J, Dale T, Powell A, Clare J, et al.
J Biol Chem
. 2010 Aug;
285(43):33404-33412.
PMID: 20675377
Electrical excitability in neurons depends on the activity of membrane-bound voltage gated sodium channels (Na(v)) that are assembled from an ion conducting α-subunit and often auxiliary β-subunits. The α-subunit isoform...
5.
Clare J
Discov Med
. 2010 Mar;
9(46):253-60.
PMID: 20350493
Ion channels are important therapeutic targets which are modulated by a range of currently prescribed drugs. Most of these were developed empirically by traditional pharmacology without knowing their precise target,...
6.
Clare J
Expert Opin Investig Drugs
. 2009 Dec;
19(1):45-62.
PMID: 20001554
Drugs inhibiting voltage-gated sodium channels have long been used as analgesics, beginning with the use of local anaesthetics for sensory blockade and then with the discovery that Nav-blocking anticonvulsants also...
7.
Redaelli E, Cassulini R, Silva D, Clement H, Schiavon E, Zamudio F, et al.
J Biol Chem
. 2009 Dec;
285(6):4130-4142.
PMID: 19955179
Venom-derived peptide modulators of ion channel gating are regarded as essential tools for understanding the molecular motions that occur during the opening and closing of ion channels. In this study,...
8.
Clare J, Chen M, Downie D, Trezise D, Powell A
Comb Chem High Throughput Screen
. 2009 Jan;
12(1):96-106.
PMID: 19149495
The tractability of ion channels as drug targets has been significantly improved by the advent of planar array electrophysiology platforms which have dramatically increased the capacity for electrophysiological profiling of...
9.
Cusdin F, Clare J, Jackson A
Traffic
. 2007 Nov;
9(1):17-26.
PMID: 17988224
Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing...
10.
Sun G, Werkman T, Battefeld A, Clare J, Wadman W
Epilepsia
. 2007 Mar;
48(4):774-82.
PMID: 17381447
Purpose: The transient and the persistent Na(+) current play a distinct role in neuronal excitability. Several antiepileptic drugs (AEDs) modulate the transient Na(+) current and block the persistent Na(+) current;...