Jeffrey D Varner
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Explore the profile of Jeffrey D Varner including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Tan M, Jenkins-Johnston N, Huang S, Schutrum B, Vadhin S, Adhikari A, et al.
APL Bioeng
. 2023 Dec;
7(4):046116.
PMID: 38058993
Breast cancer metastasis is initiated by invasion of tumor cells into the collagen type I-rich stroma to reach adjacent blood vessels. Prior work has identified that metabolic plasticity is a...
2.
Vilkhovoy M, Dammalapati S, Vadhin S, Adhikari A, Varner J
bioRxiv
. 2023 Feb;
PMID: 36798424
Cell-free protein expression has become a widely used research tool in systems and synthetic biology and a promising technology for protein biomanufacturing. Cell-free protein synthesis relies on transcription and translation...
3.
Shimpi A, Tan M, Vilkhovoy M, Dai D, Roberts L, Kuo J, et al.
Adv Healthc Mater
. 2022 Dec;
12(14):e2202224.
PMID: 36479976
Metastasis is the leading cause of breast cancer-related deaths and is often driven by invasion and cancer-stem like cells (CSCs). Both the CSC phenotype and invasion are associated with increased...
4.
Guzman-Chavez F, Arce A, Adhikari A, Vadhin S, Pedroza-Garcia J, Gandini C, et al.
ACS Synth Biol
. 2022 Mar;
11(3):1114-1128.
PMID: 35259873
Cell-free systems for gene expression have gained attention as platforms for the facile study of genetic circuits and as highly effective tools for teaching. Despite recent progress, the technology remains...
5.
Adhikari A, Vilkhovoy M, Vadhin S, Lim H, Varner J
Front Bioeng Biotechnol
. 2020 Dec;
8:539081.
PMID: 33324619
Transcription and translation are at the heart of metabolism and signal transduction. In this study, we developed an effective biophysical modeling approach to simulate transcription and translation processes. The model,...
6.
Natarajan A, Jaroentomeechai T, Cabrera-Sanchez M, Mohammed J, Cox E, Young O, et al.
Nat Chem Biol
. 2020 Jul;
16(10):1062-1070.
PMID: 32719555
A major objective of synthetic glycobiology is to re-engineer existing cellular glycosylation pathways from the top down or construct non-natural ones from the bottom up for new and useful purposes....
7.
Horvath N, Vilkhovoy M, Wayman J, Calhoun K, Swartz J, Varner J
Metab Eng Commun
. 2020 Apr;
10:e00113.
PMID: 32280586
In this study, we developed a dynamic mathematical model of cell-free protein synthesis (CFPS). Model parameters were estimated from a dataset consisting of glucose, organic acids, energy species, amino acids,...
8.
Vilkhovoy M, Dai D, Vadhin S, Adhikari A, Varner J
J Vis Exp
. 2019 Nov;
(152).
PMID: 31710042
Cell-free protein synthesis (CFPS) is an emerging technology in systems and synthetic biology for the in vitro production of proteins. However, if CFPS is going to move beyond the laboratory...
9.
Wayman J, Glasscock C, Mansell T, DeLisa M, Varner J
Metab Eng Commun
. 2019 Apr;
9:e00088.
PMID: 31008057
Asparagine-linked (-linked) glycosylation is the most common protein modification in eukaryotes, affecting over two-thirds of the proteome. Glycosylation is also critical to the pharmacokinetic activity and immunogenicity of many therapeutic...
10.
Ghaffari H, Varner J, Petzold L
Theor Biol Med Model
. 2019 Feb;
16(1):3.
PMID: 30764845
Background: Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular coagulation...