Jeffrey D Rothstein
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Explore the profile of Jeffrey D Rothstein including associated specialties, affiliations and a list of published articles.
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196
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19354
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Recent Articles
11.
Thompson E, Spead O, Akerman S, Curcio C, Zaepfel B, Kent E, et al.
bioRxiv
. 2024 Sep;
PMID: 39253499
The GC hexanucleotide repeat expansion in is the major genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Despite considerable efforts, the development of mouse models...
12.
van den Berg L, Rothstein J, Shaw P, Babu S, Benatar M, Bucelli R, et al.
Lancet Neurol
. 2024 Jul;
23(9):901-912.
PMID: 39059407
Background: Hexanucleotide repeat expansion of C9orf72 is a common genetic cause of amyotrophic lateral sclerosis (ALS). No C9orf72-targeted treatments are available. BIIB078 is an investigational antisense oligonucleotide targeting C9orf72 sense...
13.
Akcimen F, van Midden V, Akerman S, Makarious M, Rothstein J, Fang Z, et al.
Mov Disord
. 2024 Jun;
39(9):1645-1647.
PMID: 38940474
No abstract available.
14.
Tsitkov S, Valentine K, Kozareva V, Donde A, Frank A, Lei S, et al.
Nat Commun
. 2024 May;
15(1):3606.
PMID: 38697975
Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by monogenic disease alleles. To better understand sporadic ALS,...
15.
Babu S, Nicholson K, Rothstein J, Swenson A, Sampognaro P, Pant P, et al.
Brain
. 2024 Apr;
147(9):2998-3008.
PMID: 38606777
Apilimod dimesylate is a first-in-class phosphoinositide kinase, FYVE-type zinc finger-containing (PIKfyve) inhibitor with a favourable clinical safety profile and has demonstrated activity in preclinical C9orf72 and TDP-43 amyotrophic lateral sclerosis...
16.
Fare C, Rothstein J
Nucleus
. 2024 Feb;
15(1):2314297.
PMID: 38383349
The separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created...
17.
Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, et al.
Nat Metab
. 2024 Feb;
6(3):567-577.
PMID: 38378996
Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that...
18.
Rothstein J, Warlick C, Coyne A
bioRxiv
. 2024 Jan;
PMID: 38168312
The nuclear depletion and cytoplasmic aggregation of the RNA binding protein TDP-43 is widely considered a pathological hallmark of Amyotrophic Lateral Sclerosis (ALS) and related neurodegenerative diseases. Recent studies have...
19.
Rothstein J, Baskerville V, Rapuri S, Mehlhop E, Jafar-Nejad P, Rigo F, et al.
Acta Neuropathol
. 2023 Nov;
147(1):1.
PMID: 38019311
The GC repeat expansion in the C9orf72 gene is the most common genetic cause of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Many studies suggest that dipeptide repeat proteins produced from...
20.
Workman M, Lim R, Wu J, Frank A, Ornelas L, Panther L, et al.
Neuron
. 2023 Feb;
111(8):1191-1204.e5.
PMID: 36764301
Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological disease holds great promise; however, there is a lack of well-curated lines from a large array of participants....