Nancie J MacIver
Overview
Explore the profile of Nancie J MacIver including associated specialties, affiliations and a list of published articles.
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44
Citations
4366
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Recent Articles
1.
Fee B, Fee L, Menechella M, Affeldt B, Sprouse A, Bounini A, et al.
J Biol Chem
. 2024 Oct;
300(11):107883.
PMID: 39395806
The human IRGM gene has been linked to inflammatory diseases including sepsis and Crohn's disease. Decreased expression of human IRGM, or the mouse orthologues Irgm1 and Irgm2, leads to increased...
2.
Rajeev D, MacIver N
J Nutr
. 2024 Jul;
154(8):2534-2542.
PMID: 38972391
Obesity is associated with impaired immune function, characterized by inflammation, and leading to poor response to infection, impaired vaccine response, increased susceptibility to autoimmune disease, and increased risk of cancer...
3.
Greene E, Green C, Hurst J, MacIver N
Diabetes Obes Metab
. 2024 May;
26(8):3281-3289.
PMID: 38742467
Aim: To investigate if patients with diabetes taking metformin have better outcomes versus those not taking metformin following an emergency room visit for influenza. Methods: Using electronic medical records, we...
4.
Kiernan K, Alwarawrah Y, Nichols A, Danzaki K, MacIver N
Sci Rep
. 2024 Feb;
14(1):4331.
PMID: 38383709
Insulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on CD4 T cells through insulin receptor (IR) and IGF-1 receptor (IGF-1R) signaling. Here, we describe specific...
5.
Shaikh S, Beck M, Alwarawrah Y, MacIver N
Nat Rev Endocrinol
. 2023 Dec;
20(3):136-148.
PMID: 38129700
Obesity is associated with a wide range of complications, including type 2 diabetes mellitus, cardiovascular disease, hypertension and nonalcoholic fatty liver disease. Obesity also increases the incidence and progression of...
6.
Kiernan K, Nichols A, Alwarawrah Y, MacIver N
PLoS One
. 2023 Jun;
18(6):e0286470.
PMID: 37276236
Background/objectives: Leptin is an adipokine secreted in proportion to adipocyte mass and is therefore increased in obesity. Leptin signaling has been shown to directly promote inflammatory T helper 1 (Th1)...
7.
Greene E, MacIver N
Front Immunol
. 2022 Oct;
13:1025495.
PMID: 36275776
Disorders of systemic metabolism can influence immunity. Individuals with obesity are known to have increased inflammation, increased risk to select autoimmune diseases, impaired response to several infections, and impaired vaccine...
8.
Shaikh S, MacIver N, Beck M
Annu Rev Nutr
. 2022 Aug;
42:67-89.
PMID: 35995048
The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is a significant risk factor for severe outcomes from infection. This susceptibility mirrors a similar pattern with influenza infection; that...
9.
Green W, Alwarawrah Y, Al-Shaer A, Shi Q, Armstrong M, Manke J, et al.
J Infect Dis
. 2022 Aug;
227(1):92-102.
PMID: 35975968
Background: Obesity dysregulates immunity to influenza infection. Therefore, there is a critical need to investigate how obesity impairs immunity and to establish therapeutic approaches that mitigate the impact of increased...
10.
Shaw B, Lee H, Ettenger R, Grimm P, Reed E, Sarwal M, et al.
Pediatr Transplant
. 2022 Aug;
26(8):e14371.
PMID: 35938682
Background: Malnutrition, including obesity and undernutrition, among children is increasing in prevalence and is common among children on renal replacement therapy. The effect of malnutrition on the pre-transplant immune system...