Jeffrey C Bloodworth
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Explore the profile of Jeffrey C Bloodworth including associated specialties, affiliations and a list of published articles.
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11
Citations
119
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Recent Articles
1.
Lajiness J, Bloodworth J, Blankenship R, Kosins A, Cook-Mills J
J Leukoc Biol
. 2024 Sep;
116(6):1432-1445.
PMID: 39312649
In humans and in mice, maternal allergy predisposes offspring to development of allergy. In murine models, increased levels of maternal β-glucosylceramides are both necessary and sufficient for the development of...
2.
Damron C, Bloodworth J, Hoji A, Casasnovas J, Kua K, Cook-Mills J
J Leukoc Biol
. 2024 Jun;
116(5):985-994.
PMID: 38881487
Epidemiological studies demonstrate that maternal obesity and maternal allergy are major risk factors for asthma in offspring. However, the impact of maternal allergy and obesity on offspring lung insulin signaling...
3.
Walker M, Bloodworth J, Kountz T, McCarty S, Green J, Ferrie R, et al.
Front Allergy
. 2024 Jun;
5:1385168.
PMID: 38845678
Background: Previous research showed that 5-hydroxytryptophan (5HTP), a metabolic precursor of serotonin, reduces allergic lung inflammation by inhibiting eosinophil migration across endothelial monolayers. Objective: It is unknown if serotonin receptors...
4.
Okuneye K, Bergman D, Bloodworth J, Pearson A, Sweis R, Jackson T
Comput Syst Oncol
. 2022 Jan;
1(2).
PMID: 34984415
Bladder cancer is a common malignancy with over 80,000 estimated new cases and nearly 18,000 deaths per year in the United States alone. Therapeutic options for metastatic bladder cancer had...
5.
Rouhani S, Trujillo J, Pyzer A, Yu J, Fessler J, Cabanov A, et al.
Res Sq
. 2021 Nov;
PMID: 34845442
The mechanisms explaining progression to severe COVID-19 remain poorly understood. It has been proposed that immune system dysregulation/over-stimulation may be implicated, but it is not clear how such processes would...
6.
Strohbehn G, Heiss B, Rouhani S, Trujillo J, Yu J, Kacew A, et al.
Clin Pharmacol Ther
. 2020 Nov;
109(3):688-696.
PMID: 33210302
Interleukin-6 (IL-6)-mediated hyperinflammation may contribute to the mortality of coronavirus disease 2019 (COVID-19). The IL-6 receptor-blocking monoclonal antibody tocilizumab has been repurposed for COVID-19, but prospective trials and dose-finding studies...
7.
Andolfi C, Bloodworth J, Papachristos A, Sweis R
Bladder Cancer
. 2020 Nov;
6(3):225-235.
PMID: 33195783
Bladder cancer is a highly prevalent disease worldwide and is associated with a high mortality rate. Across all stages of bladder cancer, immunotherapy has now become the cornerstone of treatment....
8.
Strohbehn G, Heiss B, Rouhani S, Trujillo J, Yu J, Kacew A, et al.
medRxiv
. 2020 Aug;
PMID: 32743594
Background Interleukin-6 (IL-6)-mediated hyperinflammation may contribute to the high mortality of coronavirus disease 2019 (Covid-19). Tocilizumab, an IL-6 receptor blocking monoclonal antibody, has been repurposed for Covid-19, but prospective trials...
9.
TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
Shah N, Kumar S, Zaman N, Pan C, Bloodworth J, Lei W, et al.
Nat Commun
. 2018 Apr;
9(1):1696.
PMID: 29703898
Acetylation of microtubules (MT) confers mechanical stability necessary for numerous functions including cell cycle and intracellular transport. Although αTAT1 is a major MT acetyltransferase, how this enzyme is regulated remains...
10.
Pan C, Kumar S, Shah N, Bloodworth J, Hawinkels L, Mythreye K, et al.
J Biol Chem
. 2015 May;
290(24):14884-92.
PMID: 25931117
Autophagy is the targeted degradation of proteins and organelles critical for homeostasis and cell survival. Transforming growth factor β (TGF-β) differentially regulates autophagy in a context-specific manner, although the precise...