Jeffrey A Winkles
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Explore the profile of Jeffrey A Winkles including associated specialties, affiliations and a list of published articles.
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77
Citations
2726
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Recent Articles
1.
Seas A, Malla A, Sharifai N, Winkles J, Woodworth G, Anastasiadis P
Biomedicines
. 2024 Jun;
12(6).
PMID: 38927437
Infiltrating gliomas are challenging to treat, as the blood-brain barrier significantly impedes the success of therapeutic interventions. While some clinical trials for high-grade gliomas have shown promise, patient outcomes remain...
2.
Mahmud M, Pandey N, Winkles J, Woodworth G, Kim A
Nano Today
. 2024 Jun;
56.
PMID: 38854931
Nanotherapeutics have gained significant attention for the treatment of numerous cancers, primarily because they can accumulate in and/or selectively target tumors leading to improved pharmacodynamics of encapsulated drugs. The flexibility...
3.
Carney C, Pandey N, Kapur A, Saadi H, Ong H, Chen C, et al.
ACS Nano
. 2023 Oct;
17(20):19667-19684.
PMID: 37812740
The TWEAK receptor, Fn14, is a promising candidate for active targeting of cancer nanotherapeutics to many solid tumor types, including metastatic breast and primary brain cancers. Targeting of therapeutic nanoparticles...
4.
Carney C, Kapur A, Anastasiadis P, Ritzel R, Chen C, Woodworth G, et al.
Mol Pharm
. 2022 Nov;
20(1):314-330.
PMID: 36374573
Triple-negative breast cancer (TNBC) patients with brain metastasis (BM) face dismal prognosis due to the limited therapeutic efficacy of the currently available treatment options. We previously demonstrated that paclitaxel-loaded PLGA-PEG...
5.
Spina R, Mills I, Ahmad F, Chen C, Ames H, Winkles J, et al.
Oncogene
. 2022 Nov;
41(50):5361-5372.
PMID: 36344676
Glioma stem cells (GSCs) promote tumor progression and therapeutic resistance and exhibit remarkable bioenergetic and metabolic plasticity, a phenomenon that has been linked to their ability to escape standard and...
6.
Kim A, Winkles J, Woodworth G
Adv Drug Deliv Rev
. 2022 Aug;
189:114522.
PMID: 36030017
No abstract available.
7.
Pandey N, Anastasiadis P, Carney C, Kanvinde P, Woodworth G, Winkles J, et al.
Adv Drug Deliv Rev
. 2022 Jul;
188:114415.
PMID: 35787387
Glioblastoma (GBM) is the most common malignant adult brain cancer with no curative treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to the brain-invading tumor cells...
8.
Pang S, Kapur A, Zhou K, Anastasiadis P, Ballirano N, Kim A, et al.
Wiley Interdiscip Rev Nanomed Nanobiotechnol
. 2022 Jun;
14(5):e1826.
PMID: 35735205
Laser interstitial thermal therapy (LITT) guided by magnetic resonance imaging (MRI) is a new treatment option for patients with brain and non-central nervous system (non-CNS) tumors. MRI guidance allows for...
9.
Carney C, Pandey N, Kapur A, Woodworth G, Winkles J, Kim A
Drug Deliv Transl Res
. 2021 Oct;
11(6):2344-2370.
PMID: 34716900
Brain metastases (BMs) are the most common type of brain tumor, and the incidence among breast cancer (BC) patients has been steadily increasing over the past two decades. Indeed, ~ ...
10.
Connolly N, Galisteo R, Xu S, Bar E, Peng S, Tran N, et al.
Glia
. 2021 May;
69(9):2199-2214.
PMID: 33991013
High-grade gliomas (HGGs) are aggressive, treatment-resistant, and often fatal human brain cancers. The TNF-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) signaling axis is involved in tissue repair...