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Jeff DeMartino

Explore the profile of Jeff DeMartino including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 103
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Recent Articles
1.
Kluiver T, Lu Y, Schubert S, Kraaier L, Ringnalda F, Lijnzaad P, et al.
Nat Commun . 2024 Nov; 15(1):8576. PMID: 39567475
Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we perform...
2.
Hendriks D, Pagliaro A, Andreatta F, Ma Z, van Giessen J, Massalini S, et al.
Cell . 2024 Jan; 187(3):712-732.e38. PMID: 38194967
Human brain development involves an orchestrated, massive neural progenitor expansion while a multi-cellular tissue architecture is established. Continuously expanding organoids can be grown directly from multiple somatic tissues, yet to...
3.
Lin L, DeMartino J, Wang D, van Son G, van der Linden R, Begthel H, et al.
Science . 2023 Oct; 382(6669):451-458. PMID: 37883554
Enteroendocrine cells (EECs) are hormone-producing cells residing in the epithelium of stomach, small intestine (SI), and colon. EECs regulate aspects of metabolic activity, including insulin levels, satiety, gastrointestinal secretion, and...
4.
DeMartino J, Meister M, Visser L, Brok M, Groot Koerkamp M, Wezenaar A, et al.
Nat Commun . 2023 May; 14(1):3074. PMID: 37244912
Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin that is thought to arise as a consequence of derailed myogenic differentiation. Despite intensive treatment regimens, the prognosis for...
5.
He G, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, et al.
Cell Stem Cell . 2022 Dec; 29(12):1718-1720. PMID: 36459971
No abstract available.
6.
He G, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, et al.
Cell Stem Cell . 2022 Aug; 29(9):1333-1345.e6. PMID: 36002022
Opposing roles have been proposed for IL-22 in intestinal pathophysiology. We have optimized human small intestinal organoid (hSIO) culturing, constitutively generating all differentiated cell types while maintaining an active stem...
7.
Meister M, Groot Koerkamp M, de Souza T, Breunis W, Frazer-Mendelewska E, Brok M, et al.
EMBO Mol Med . 2022 Aug; 14(10):e16001. PMID: 35916583
Rhabdomyosarcomas (RMS) are mesenchyme-derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for high-risk patients. Discovery of new therapies would benefit...