Harry Begthel
Overview
Explore the profile of Harry Begthel including associated specialties, affiliations and a list of published articles.
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Articles
67
Citations
14453
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Recent Articles
1.
Pleguezuelos-Manzano C, Beenker W, van Son G, Begthel H, Amatngalim G, Beekman J, et al.
Sci Rep
. 2025 Jan;
15(1):2222.
PMID: 39824906
Pseudomonas aeruginosa is a Gram-negative bacterium that is notorious for airway infections in cystic fibrosis (CF) subjects. Bacterial quorum sensing (QS) coordinates virulence factor expression and biofilm formation at population...
2.
Andersson-Rolf A, Groot K, Korving J, Begthel H, Hanegraaf M, VanInsberghe M, et al.
Cell
. 2024 Dec;
187(26):7394-7413.e22.
PMID: 39626658
The mammalian pancreas consists of three epithelial compartments: the acini and ducts of the exocrine pancreas and the endocrine islets of Langerhans. Murine studies indicate that these three compartments derive...
3.
Mizutani T, Boretto M, Lim S, Drost J, Gonzalez D, Oka R, et al.
Nat Cancer
. 2024 Nov;
5(12):1852-1867.
PMID: 39487295
Carcinogenesis results from the sequential acquisition of oncogenic mutations that convert normal cells into invasive, metastasizing cancer cells. Colorectal cancer exemplifies this process through its well-described adenoma-carcinoma sequence, modeled previously...
4.
Huang L, Bernink J, Giladi A, Krueger D, van Son G, Geurts M, et al.
Nature
. 2024 Oct;
634(8035):929-935.
PMID: 39358509
In mice, intestinal tuft cells have been described as a long-lived, postmitotic cell type. Two distinct subsets have been identified: tuft-1 and tuft-2 (ref. ). By combining analysis of primary...
5.
Lim S, van Son G, Wisma Eka Yanti N, Andersson-Rolf A, Willemsen S, Korving J, et al.
Cell Rep
. 2024 Mar;
43(4):114019.
PMID: 38551965
Thymic epithelial cells (TECs) orchestrate T cell development by imposing positive and negative selection on thymocytes. Current studies on TEC biology are hampered by the absence of long-term ex vivo...
6.
Boretto M, Geurts M, Gandhi S, Ma Z, Staliarova N, Celotti M, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(12):e2309902121.
PMID: 38483988
FBXW7 is an E3 ubiquitin ligase that targets proteins for proteasome-mediated degradation and is mutated in various cancer types. Here, we use CRISPR base editors to introduce different hotspot mutations...
7.
Bannier-Helaouet M, Korving J, Ma Z, Begthel H, Giladi A, Lamers M, et al.
Cell Stem Cell
. 2024 Jan;
31(2):227-243.e12.
PMID: 38215738
The conjunctival epithelium covering the eye contains two main cell types: mucus-producing goblet cells and water-secreting keratinocytes, which present mucins on their apical surface. Here, we describe long-term expanding organoids...
8.
Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease
Yengej F, Pou Casellas C, Ammerlaan C, Olde Hanhof C, Dilmen E, Beumer J, et al.
Cell Rep
. 2023 Dec;
43(1):113614.
PMID: 38159278
Organoid technology is rapidly gaining ground for studies on organ (patho)physiology. Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The progenitor state of expanding tubuloids comes...
9.
Dayton T, Alcala N, Moonen L, den Hartigh L, Geurts V, Mangiante L, et al.
Cancer Cell
. 2023 Dec;
41(12):2083-2099.e9.
PMID: 38086335
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for patients with NENs are limited, in part due to lack of accurate models....
10.
Lin L, DeMartino J, Wang D, van Son G, van der Linden R, Begthel H, et al.
Science
. 2023 Oct;
382(6669):451-458.
PMID: 37883554
Enteroendocrine cells (EECs) are hormone-producing cells residing in the epithelium of stomach, small intestine (SI), and colon. EECs regulate aspects of metabolic activity, including insulin levels, satiety, gastrointestinal secretion, and...