Jeddidiah W D Griffin
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Explore the profile of Jeddidiah W D Griffin including associated specialties, affiliations and a list of published articles.
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10
Citations
206
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Recent Articles
1.
Griffin J, Bradshaw P
Protein J
. 2021 Feb;
40(2):175-183.
PMID: 33566321
Alzheimer's disease (AD) patients could benefit from a more effective treatment than the current FDA-approved options. Because amyloid-beta (Aβ) is thought to play a central role in AD pathogenesis, many...
2.
SARS-CoV and SARS-CoV-2 main protease residue interaction networks change when bound to inhibitor N3
Griffin J
J Struct Biol
. 2020 Jul;
211(3):107575.
PMID: 32653646
COVID-19 is a respiratory disease caused by the coronavirus SARS-CoV-2. SARS-CoV-2 has many similarities with SARS-CoV. Both viruses rely on a protease called the main protease, or M, for replication....
3.
Griffin J, Bradshaw P
Theor Biol Med Model
. 2019 Aug;
16(1):11.
PMID: 31366360
Background: After proteolysis, the majority of released amino acids from dietary protein are transported to the liver for gluconeogenesis or to peripheral tissues where they are used for protein synthesis...
4.
Griffin J, Bradshaw P
BMC Struct Biol
. 2018 Jul;
18(1):9.
PMID: 30029603
Background: Amyloidogenic proteins are most often associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, but there are more than two dozen human proteins known to...
5.
Griffin J, Liu Y, Bradshaw P, Wang K
J Mol Neurosci
. 2018 Feb;
64(3):385-396.
PMID: 29441491
Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such...
6.
Delic V, Griffin J, Zivkovic S, Zhang Y, Phan T, Gong H, et al.
Neuromolecular Med
. 2017 Jun;
19(2-3):322-344.
PMID: 28620826
Parkinson's disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein accumulation and loss of dopaminergic neurons in the substantia nigra (SN) region of the brain. Increased levels of alpha-synuclein have...
7.
Griffin J, Bradshaw P
Oxid Med Cell Longev
. 2017 Mar;
2017:5472792.
PMID: 28261376
There is a dire need to discover new targets for Alzheimer's disease (AD) drug development. Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in...
8.
Ren J, Zhao J, Dai J, Griffin J, Wang L, Wu X, et al.
Immunology
. 2016 May;
148(4):377-86.
PMID: 27149428
T cells play a pivotal role in controlling viral infection; however, the precise mechanisms responsible for regulating T-cell differentiation and function during infections are incompletely understood. In this study, we...
9.
Li G, Zhou Y, Ying R, Shi L, Cheng Y, Ren J, et al.
Hepatology
. 2014 Dec;
61(4):1163-73.
PMID: 25477247
Unlabelled: T cells play a crucial role in viral clearance or persistence; however, the precise mechanisms that control their responses during viral infection remain incompletely understood. MicroRNA (miR) has been...
10.
Shi L, Wang J, Ren J, Cheng Y, Ying R, Wu X, et al.
J Immunol
. 2013 Dec;
192(2):649-57.
PMID: 24337749
Coinfection of hepatitis B virus (HBV) with hepatitis C virus (HCV) is quite common, leading to an increase in morbidity and mortality. As such, HBV vaccination is recommended in HCV-infected...