Jed J W Wiltzius
Overview
Explore the profile of Jed J W Wiltzius including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
1963
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0
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Recent Articles
1.
Alabanza L, Pegues M, Geldres C, Shi V, Wiltzius J, Sievers S, et al.
Mol Ther
. 2017 Aug;
25(11):2452-2465.
PMID: 28807568
Anti-CD19 chimeric antigen receptor (CAR) T cells have caused remissions of B cell malignancies, but problems including cytokine-mediated toxicity and short persistence of CAR T cells in vivo might limit...
2.
Apostol M, Wiltzius J, Sawaya M, Cascio D, Eisenberg D
Biochemistry
. 2011 Feb;
50(13):2456-63.
PMID: 21323366
Prion represents a unique class of pathogens devoid of nucleic acid. The deadly diseases transmitted by it between members of one species and, in certain instances, to members of other...
3.
Wiltzius J, Landau M, Nelson R, Sawaya M, Apostol M, Goldschmidt L, et al.
Nat Struct Mol Biol
. 2009 Aug;
16(9):973-8.
PMID: 19684598
In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells...
4.
Wiltzius J, Sievers S, Sawaya M, Eisenberg D
Protein Sci
. 2009 May;
18(7):1521-30.
PMID: 19475663
Islet Amyloid Polypeptide (IAPP or amylin) is a peptide hormone produced and stored in the beta-islet cells of the pancreas along with insulin. IAPP readily forms amyloid fibrils in vitro,...
5.
Wiltzius J, Sievers S, Sawaya M, Cascio D, Popov D, Riekel C, et al.
Protein Sci
. 2008 Jun;
17(9):1467-74.
PMID: 18556473
Human islet amyloid polypeptide (IAPP or amylin) is a 37-residue hormone found as fibrillar deposits in pancreatic extracts of nearly all type II diabetics. Although the cellular toxicity of IAPP...
6.
Sawaya M, Sambashivan S, Nelson R, Ivanova M, Sievers S, Apostol M, et al.
Nature
. 2007 May;
447(7143):453-7.
PMID: 17468747
Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the...
7.
Wiltzius J, Hohl M, Fleming J, Petrini J
Nat Struct Mol Biol
. 2005 Apr;
12(5):403-7.
PMID: 15852023
The Mre11 complex (in Saccharomyces cerevisiae: Mre11, Rad50 and Xrs2) influences multiple facets of chromosome break metabolism. A conserved feature of the Mre11 complex is a zinc-coordinating motif in Rad50...
8.
Li S, Schmitz K, Jeffrey P, Wiltzius J, Kussie P, Ferguson K
Cancer Cell
. 2005 Apr;
7(4):301-11.
PMID: 15837620
Recent structural studies of epidermal growth factor receptor (EGFR) family extracellular regions have identified an unexpected mechanism for ligand-induced receptor dimerization that has important implications for activation and inhibition of...