Jean van den Elsen
Overview
Explore the profile of Jean van den Elsen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
17
Citations
395
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Adams R, Joyce C, Kuravskiy M, Harrison K, Ahdash Z, Balmforth M, et al.
Front Immunol
. 2023 May;
14:1170357.
PMID: 37251411
Background: Serum albumin binding is an established mechanism to extend the serum half-life of antibody fragments and peptides. The cysteine rich knob domains, isolated from bovine antibody ultralong CDRH3, are...
2.
Wonfor T, Li S, Dunphy R, Macpherson A, van den Elsen J, Laabei M
Sci Rep
. 2022 Sep;
12(1):15766.
PMID: 36130996
The primary host response to Staphylococcus aureus infection occurs via complement. Complement is an elegant evolutionarily conserved system, playing essential roles in early defences by working in concert with immune...
3.
Hawkins A, Joyce C, Brady K, Hold A, Smith A, Knight M, et al.
MAbs
. 2022 May;
14(1):2076295.
PMID: 35634719
Cysteine-rich knob domains can be isolated from the ultralong heavy-chain complementarity-determining region (CDR) 3, which are unique to a subset of bovine antibodies, to create antibody fragments of ~4 kDa....
4.
Macpherson A, Birtley J, Broadbridge R, Brady K, Schulze M, Tang Y, et al.
ACS Chem Biol
. 2021 Aug;
16(9):1757-1769.
PMID: 34406751
Cysteine-rich knob domains found in the ultralong complementarity determining regions of a subset of bovine antibodies are capable of functioning autonomously as 3-6 kDa peptides. While they can be expressed...
5.
Nilsson P, Johnson C, Quach Q, Macpherson A, Durrant O, Pischke S, et al.
J Immunol
. 2021 Aug;
207(6):1641-1651.
PMID: 34380648
Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept...
6.
Macpherson A, Scott-Tucker A, Spiliotopoulos A, Simpson C, Staniforth J, Hold A, et al.
PLoS Biol
. 2020 Sep;
18(9):e3000821.
PMID: 32886672
As a novel alternative to established surface display or combinatorial chemistry approaches for the discovery of therapeutic peptides, we present a method for the isolation of small, cysteine-rich domains from...
7.
Turpin C, Catan A, Guerin-Dubourg A, Debussche X, Bravo S, Alvarez E, et al.
PLoS One
. 2020 Jul;
15(7):e0235335.
PMID: 32628695
Diabetes is associated with a dramatic mortality rate due to its vascular complications. Chronic hyperglycemia in diabetes leads to enhanced glycation of erythrocytes and oxidative stress. Even though erythrocytes play...
8.
Macpherson A, Liu X, Dedi N, Kennedy J, Carrington B, Durrant O, et al.
J Biol Chem
. 2018 Jul;
293(36):14112-14121.
PMID: 30030376
Complement component C5 is the target of the mAb eculizumab and is the focus of a sustained drug discovery effort to prevent complement-induced inflammation in a range of autoimmune diseases....
9.
Chen Y, Smith T, Hicks R, Doekhie A, Koumanov F, Wells S, et al.
Sci Rep
. 2017 Apr;
7:46568.
PMID: 28436442
Biological substances based on proteins, including vaccines, antibodies, and enzymes, typically degrade at room temperature over time due to denaturation, as proteins unfold with loss of secondary and tertiary structure....
10.
Kassaar O, Pereira Morais M, Xu S, Adam E, Chamberlain R, Jenkins B, et al.
Sci Rep
. 2017 Apr;
7:45417.
PMID: 28378744
No abstract available.