Jean H M Feyen
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Explore the profile of Jean H M Feyen including associated specialties, affiliations and a list of published articles.
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35
Citations
752
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Recent Articles
1.
Martens C, Van Mol P, Wauters J, Wauters E, Gangnus T, Noppen B, et al.
EBioMedicine
. 2022 Aug;
83:104195.
PMID: 35939907
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system. Its dysregulation may lead to increased vascular...
2.
Van Bergen T, Hu T, Little K, De Groef L, Moons L, Stitt A, et al.
Invest Ophthalmol Vis Sci
. 2021 Oct;
62(13):18.
PMID: 34677569
Purpose: To investigate the effect of plasma kallikrein (PKal)-inhibition by THR-149 on preventing key pathologies associated with diabetic macular edema (DME) in a rat model. Methods: Following streptozotocin-induced diabetes, THR-149...
3.
Van Hove I, Hu T, Beets K, Van Bergen T, Etienne I, Stitt A, et al.
Prog Retin Eye Res
. 2021 Mar;
85:100966.
PMID: 33775825
Integrins are a class of transmembrane receptors that are involved in a wide range of biological functions. Dysregulation of integrins has been implicated in many pathological processes and consequently, they...
4.
Van Bergen T, Etienne I, Jia J, Li J, Vlodavsky I, Stitt A, et al.
Curr Eye Res
. 2020 Dec;
46(8):1166-1170.
PMID: 33372561
Purpose: Pentosan polysulfate sodium (PPS; Elmiron) is a FDA-approved heparanase inhibitor for the treatment of bladder pain and interstitial cystitis. The chronic use of PPS has been associated with a...
5.
Van Hove I, De Groef L, Boeckx B, Modave E, Hu T, Beets K, et al.
Diabetologia
. 2020 Aug;
63(10):2235-2248.
PMID: 32734440
Aims/hypothesis: Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim...
6.
Willekens K, Gijbels A, Smits J, Schoevaerdts L, Blanckaert J, Feyen J, et al.
Acta Ophthalmol
. 2020 Jul;
99(1):90-96.
PMID: 32701225
Purpose: To evaluate the safety and feasibility of robot-assisted retinal vein cannulation with Ocriplasmin infusion for central retinal vein occlusion. Methods: Prospective phase I trial including four patients suffering from...
7.
Sergeys J, Van Hove I, Hu T, Temps C, Carragher N, Unciti-Broceta A, et al.
Exp Eye Res
. 2020 Jun;
197:108108.
PMID: 32590005
Although anti-VEGF therapies have radically changed clinical practice, there is still an urgent demand for novel, integrative approaches for sight-threatening retinal vascular diseases. As we hypothesize that protein tyrosine kinases...
8.
Cunningham F, Van Bergen T, Canning P, Lengyel I, Feyen J, Stitt A
Curr Eye Res
. 2019 May;
44(8):813-822.
PMID: 31055948
There is growing evidence that placental growth factor (PlGF) is an important player in multiple pathologies, including tumorigenesis, inflammatory disorders and degenerative retinopathies. PlGF is a member of the vascular...
9.
Sergeys J, Etienne I, Van Hove I, Lefevere E, Stalmans I, Feyen J, et al.
Invest Ophthalmol Vis Sci
. 2019 Feb;
60(2):807-822.
PMID: 30811545
Purpose: The goal of this study was to perform an extensive temporal characterization of the early pathologic processes in the streptozotocin (STZ)-induced diabetic retinopathy (DR) mouse model, beyond the vascular...
10.
Hu T, Vanhove M, Porcu M, Van Hove I, Van Bergen T, Jonckx B, et al.
Exp Eye Res
. 2018 Nov;
180:43-52.
PMID: 30472075
Integrins are associated with various eye diseases such as diabetic retinopathy (DR) and wet age-related macular degeneration (AMD) and implicated in main pathologic disease hallmarks like neovascularization, inflammation, fibrosis and...