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Jean Gauthier

Explore the profile of Jean Gauthier including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 108
Followers 0
Related Specialties
Biochemistry
Oncology
Cardiology & Vascular Diseases
Top 10 Co-Authors
George Kukolj
Ginette McKercher
Pierre L Beaulieu
Marc-Andre Poupart
Bernard Vidalinc
Pierre Daumar
Clemence Dubois
Corinne Aubel
Sylvie Goulet
Mahchid Bamdad
Published In
Bioorg Med Chem Lett
Cancers (Basel)
Can J Urol
J Med Chem
J Clin Med
Affiliations
Soon will be listed here.
Recent Articles
1.
LightSpot-FL-1 Fluorescent Probe: An Innovative Tool for Cancer Drug Resistance Analysis by Direct Detection and Quantification of the P-glycoprotein (P-gp) on Monolayer Culture and Spheroid Triple Negative Breast Cancer Models
Goisnard A, Daumar P, Dubois C, Aubel C, Roux M, Depresle M, et al.
Cancers (Basel) . 2021 Aug; 13(16). PMID: 34439204
P-gp is the most widely studied MDR protein conferring cellular resistance to many standard or targeted therapeutic agents. For this reason, P-gp chemoresistance evaluation, established before or during chemotherapy, can...
2.
The New Serum-Free OptiPASS Medium in Cold and Oxygen-Free Conditions: An Innovative Conservation Method for the Preservation of MDA-MB-231 Triple Negative Breast Cancer Spheroids
Goisnard A, Dubois C, Daumar P, Aubel C, Depresle M, Gauthier J, et al.
Cancers (Basel) . 2021 Apr; 13(8). PMID: 33919619
Cancer spheroids are very effective preclinical models to improve anticancer drug screening. In order to optimize and extend the use of spheroid models, these works were focused on the development...
3.
Epidemiological characteristics and therapeutic management of patients with chronic heart failure who use smartphones: Potential impact of a dedicated smartphone application (report from the OFICSel study)
Pezel T, Berthelot E, Gauthier J, Chong-Nguyen C, Iliou M, Juilliere Y, et al.
Arch Cardiovasc Dis . 2020 Sep; 114(1):51-58. PMID: 32868257
Background: The effectiveness of transitional care services for patients discharged from hospital after acute heart failure is challenging, especially in terms of reducing subsequent heart failure hospitalizations. The increased adoption...
4.
The New Synthetic Serum-Free Medium OptiPASS Promotes High Proliferation and Drug Efficacy Prediction on Spheroids from MDA-MB-231 and SUM1315 Triple-Negative Breast Cancer Cell Lines
Dubois C, Daumar P, Aubel C, Gauthier J, Vidalinc B, Mounetou E, et al.
J Clin Med . 2019 Mar; 8(3). PMID: 30901969
Triple-negative breast cancers are particularly aggressive. In vitro cultures are one of the major pathways for developing anticancer strategies. The effectiveness and reproducibility of the drug screenings depend largely on...
5.
Alterations in echocardiographic and electrocardiographic features in Japanese professional soccer players: comparison to African-Caucasian ethnicities
Kervio G, Pelliccia A, Nagashima J, Wilson M, Gauthier J, Murayama M, et al.
Eur J Prev Cardiol . 2012 May; 20(5):880-8. PMID: 22548966
Background: Scarce data are available regarding the electrocardiographic (ECG) and echocardiographic changes in athletes of Asian origin. Design: We investigate the ECG and echocardiographic patterns in Japanese (J) compared with...
6.
Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase
Kukolj G, McGibbon G, McKercher G, Marquis M, Lefebvre S, Thauvette L, et al.
J Biol Chem . 2005 Sep; 280(47):39260-7. PMID: 16188890
The virally encoded NS5B RNA-dependent RNA polymerase has emerged as a prime target in the search for specific HCV antivirals. A series of benzimidazole 5-carboxamide compounds inhibit the cellular RNA...
7.
Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells
Beaulieu P, Bousquet Y, Gauthier J, Gillard J, Marquis M, McKercher G, et al.
J Med Chem . 2004 Dec; 47(27):6884-92. PMID: 15615537
A previously disclosed series of non-nucleoside allosteric inhibitors of the NS5B polymerase of the hepatitis C virus (HCV) was optimized to yield novel compounds with improved physicochemical properties and activity...
8.
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency
Beaulieu P, Bos M, Bousquet Y, DeRoy P, Fazal G, Gauthier J, et al.
Bioorg Med Chem Lett . 2004 Mar; 14(4):967-71. PMID: 15013003
Optimization of benzimidazole 5-carboxamide derivatives previously identified as specific inhibitors of the NS5B polymerase of the hepatitis C virus (HCV) has led to the discovery of potent analogues that inhibit...
9.
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives
Beaulieu P, Bos M, Bousquet Y, Fazal G, Gauthier J, Gillard J, et al.
Bioorg Med Chem Lett . 2003 Dec; 14(1):119-24. PMID: 14684311
Benzimidazole 5-carboxamide derivatives from a combinatorial screening library were discovered as specific inhibitors of the NS5B polymerase of the hepatitis C virus (HCV). Initial hit-to-lead activities taking advantage of high-throughput...
10.
[Blood doping and cardiovascular consequences]
Gauthier J
Presse Med . 2003 Feb; 31(40):1904-8. PMID: 12579085
Unlabelled: THE REASONS FOR BLOOD DOPING: The aim of doping the hematological functions is to increase the quantity of oxygen supplied to the muscles in activity. THE DOPING METHODS: Self...