Jean E Schwarzbauer
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Explore the profile of Jean E Schwarzbauer including associated specialties, affiliations and a list of published articles.
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86
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Recent Articles
1.
Resnikoff H, Schwarzbauer J
Mol Biol Cell
. 2024 Jul;
35(9):ar120.
PMID: 39046775
Endothelial cell behavior is regulated by subendothelial extracellular matrix (ECM). The ECM protein fibronectin (FN) is rare in healthy blood vessels but accumulates in disease accompanied by endothelial dysfunctions. Here,...
2.
Sun Y, King B, Hamlin A, Saniepay M, Gorshkov K, Barker G, et al.
Cells Dev
. 2024 Jul;
179:203941.
PMID: 39038657
The extracellular matrix (ECM) is a critical component of tissue where it provides structural and signaling support to cells. Its dysregulation and accumulation lead to fibrosis, a major clinical challenge...
3.
Sharma A, Hill K, Schwarzbauer J
Front Cell Neurosci
. 2023 Jun;
17:1177663.
PMID: 37388410
The composition of the extracellular matrix (ECM) in nervous tissue plays an important role in controlling neuronal outgrowth and synapse development. Changes in both protein and glycosaminoglycan components of the...
4.
Siddiqui A, Thiele F, Stewart R, Rangnick S, Weiss G, Chen B, et al.
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37373396
The spinal cord has a poor ability to regenerate after an injury, which may be due to cell loss, cyst formation, inflammation, and scarring. A promising approach to treating a...
5.
Lovett B, Hill K, Randolph E, Wang L, Schwarzbauer J
J Biol Chem
. 2023 Mar;
299(5):104622.
PMID: 36933809
Fibronectin (FN), a critical component of the extracellular matrix, is assembled into fibrils through a cell-mediated process. Heparan sulfate (HS) binds to the III module of FN, and fibroblasts lacking...
6.
Tomer D, Arriagada C, Munshi S, Alexander B, French B, Vedula P, et al.
J Cell Sci
. 2022 Jul;
135(16).
PMID: 35851804
Fibronectin (Fn1) fibrils have long been viewed as continuous fibers composed of extended, periodically aligned Fn1 molecules. However, our live-imaging and single-molecule localization microscopy data are inconsistent with this traditional...
7.
Resnikoff H, Miller C, Schwarzbauer J
Exp Biol Med (Maywood)
. 2022 Apr;
247(13):1093-1102.
PMID: 35410521
Fibrosis is an accumulation of extracellular matrix (ECM) proteins and fibers in a disordered fashion, which compromises cell and tissue functions. High glucose-induced fibrosis, a major pathophysiological change of diabetic...
8.
Hill K, Lovett B, Schwarzbauer J
J Biol Chem
. 2021 Dec;
298(1):101479.
PMID: 34890641
Fibronectin (FN), an essential component of the extracellular matrix (ECM), is assembled via a cell-mediated process in which integrin receptors bind secreted FN and mediate its polymerization into fibrils that...
9.
Sharma A, Schwarzbauer J
Mol Neurobiol
. 2021 Nov;
59(2):1112-1123.
PMID: 34845592
The extracellular matrix (ECM) plays a critical role in development, homeostasis, and regeneration of tissue structures and functions. Cell interactions with the ECM are dynamic and cells respond to ECM...
10.
Miller C, Henderson M, Mantopoulos D, Leskov I, Greco T, Schwarzbauer J, et al.
Ophthalmic Surg Lasers Imaging Retina
. 2021 Jul;
52(S1):S5-S12.
PMID: 34310239
Background And Objective: Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment repair failure. However, the molecular pathogenesis remains incompletely understood. Determining the proteome of PVR will help to...