Jean-Yves Le Guennec
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Explore the profile of Jean-Yves Le Guennec including associated specialties, affiliations and a list of published articles.
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57
Citations
1232
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Recent Articles
1.
Capdevila M, Pensier J, De Jong A, Jung B, Beghin J, Laumon T, et al.
Anesthesiology
. 2025 Jan;
PMID: 39854688
Background: Long-term controlled mechanical ventilation (CMV) in intensive care unit (ICU) induces ventilatory-induced-diaphragm-dysfunction (VIDD). The transition from CMV to assisted mechanical ventilation is a challenge that requires clinicians to balance...
2.
Bechard E, Arel E, Bride J, Louradour J, Bussy X, Elloumi A, et al.
Sci Rep
. 2024 Jul;
14(1):15244.
PMID: 38956407
TREK-1 is a mechanosensitive channel activated by polyunsaturated fatty acids (PUFAs). Its activation is supposed to be linked to changes in membrane tension following PUFAs insertion. Here, we compared the...
3.
Champeroux P, Thireau J, Le Guennec J, Fares R
J Pharmacol Toxicol Methods
. 2024 May;
127:107512.
PMID: 38719163
The principle of proportionality of the systolic area of the central aortic pressure to stroke volume (SV) has been long known. The aim of the present work was to evaluate...
4.
Elloumi A, Mas-Normand L, Bride J, Reversat G, Bultel-Ponce V, Guy A, et al.
Sci Data
. 2024 Feb;
11(1):193.
PMID: 38351090
Oxylipins, small polar molecules derived from the peroxidation of polyunsaturated fatty acids (PUFAs), serve as biomarkers for many diseases and play crucial roles in human physiology and inflammation. Despite their...
5.
Bechard E, Bride J, Le Guennec J, Brette F, Demion M
Front Physiol
. 2023 Jan;
13:1095102.
PMID: 36620226
The TREK-1 channel belongs to the TREK subfamily of two-pore domains channels that are activated by stretch and polyunsaturated fatty acids and inactivated by Protein Kinase A phosphorylation. The activation...
6.
Champeroux P, Fares R, Bastogne T, Richard S, Le Guennec J, Thireau J
Br J Pharmacol
. 2022 Jun;
179(18):4549-4562.
PMID: 35751378
Background And Purpose: HERG blocking drugs known for their propensity to trigger Torsades de Pointes (TdP) were reported to induce a sympatho-vagal coactivation and to enhance High Frequency heart rate...
7.
Arel E, Rolland L, Thireau J, Torrente A, Bechard E, Bride J, et al.
Biology (Basel)
. 2022 Apr;
11(4).
PMID: 35453802
The use of zebrafish to explore cardiac physiology has been widely adopted within the scientific community. Whether this animal model can be used to determine drug cardiac toxicity via electrocardiogram...
8.
Louradour J, Bortolotti O, Torre E, Bidaud I, Lamb N, Fernandez A, et al.
Cells
. 2022 Apr;
11(7).
PMID: 35406677
Background: Sinoatrial node cells (SANC) automaticity is generated by functional association between the activity of plasmalemmal ion channels and local diastolic intracellular Ca release (LCR) from ryanodine receptors. Strikingly, most...
9.
Brette F, Le Guennec J, Thireau J
J Gen Physiol
. 2022 Mar;
154(4).
PMID: 35297958
No abstract available.
10.
Hedon C, Lambert K, Chakouri N, Thireau J, Aimond F, Cassan C, et al.
Prog Biophys Mol Biol
. 2020 Oct;
159:105-117.
PMID: 33031824
The transient receptor potential Melastatin 4 (TRPM4) channel is a calcium-activated non-selective cation channel expressed widely. In the heart, using a knock-out mouse model, the TRPM4 channel has been shown...