Jean-Jacques Lacapere
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Explore the profile of Jean-Jacques Lacapere including associated specialties, affiliations and a list of published articles.
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61
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1481
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Recent Articles
1.
Duma L, Schneider S, Martinez A, Hachet C, Bihel F, Lacapere J
Biochimie
. 2025 Feb;
PMID: 39914698
Translocator protein (TSPO, 18 kDa), previously known as peripheral-type benzodiazepine receptor, is an evolutionarily conserved membrane protein involved in various physiological processes and patho-physiological conditions. The endogeneous TSPO ligand is...
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Guillemain G, Khemtemourian L, Brehat J, Morin D, Movassat J, Tourrel-Cuzin C, et al.
Biochimie
. 2024 Jun;
224:104-113.
PMID: 38908539
Amyloidosis forms a large family of pathologies associated with amyloid deposit generated by the formation of amyloid fibrils or plaques. The amyloidogenic proteins and peptides involved in these processes are...
4.
Saade C, Pozza A, Bonnete F, Finet S, Lutz-Bueno V, Tully M, et al.
Biochimie
. 2024 Apr;
224:3-15.
PMID: 38663457
TSPO is a ubiquitous transmembrane protein used as a pharmacological marker in neuroimaging. The only known atomic structure of mammalian TSPOs comes from the solution NMR of mouse TSPO (mTSPO)...
5.
Duport C, Armengaud J, Schmitt C, Morin D, Lacapere J
Biochimie
. 2024 Feb;
224:51-61.
PMID: 38423451
A structural homolog of the mammalian TSPO has been identified in the human pathogen Bacillus cereus. BcTSPO, in its recombinant form, has previously been shown to bind and degrade porphyrins....
6.
Issop L, Duma L, Finet S, Lequin O, Lacapere J
Biochimie
. 2024 Jan;
224:16-28.
PMID: 38280504
Overexpression of recombinant Bacillus cereus TSPO (BcTSPO) in E. coli bacteria leads to its recovery with a bound hemin both in bacterial membrane (MB) and inclusion bodies (IB). Unlike mouse...
7.
Combet S, Bonnete F, Finet S, Pozza A, Saade C, Martel A, et al.
Biochimie
. 2022 Dec;
205:61-72.
PMID: 36460205
The translocator protein (TSPO) is a ubiquitous transmembrane protein of great pharmacological interest thanks to its high affinity to many drug ligands. The only high-resolution 3D-structure known for mammalian TSPO...
8.
Duma L, Senicourt L, Rigaud B, Papadopoulos V, Lacapere J
Biochimie
. 2022 Aug;
205:73-85.
PMID: 36029902
In the last decades, ligand binding to human TSPO has been largely used in clinical neuroimaging, but little is known about the interaction mechanism. Protein conformational mobility plays a key...
9.
Guillemain G, Lacapere J, Khemtemourian L
Biochim Biophys Acta Biomembr
. 2022 Jul;
1864(10):184002.
PMID: 35868406
Loss of pancreatic β-cell mass is deleterious for type 2 diabetes patients since it reduces insulin production, critical for glucose homeostasis. The main research axis developed over the last few...
10.
Ostuni M, Hermand P, Saindoy E, Guillou N, Guellec J, Coens A, et al.
Sci Rep
. 2020 Jun;
10(1):9069.
PMID: 32494000
During inflammatory response, blood leukocytes adhere to the endothelium. This process involves numerous adhesion molecules, including a transmembrane chemokine, CX3CL1, which behaves as a molecular cluster. How this cluster assembles...