Jayne M Stommel
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Explore the profile of Jayne M Stommel including associated specialties, affiliations and a list of published articles.
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17
Citations
3552
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Recent Articles
1.
Kong B, Stommel J, Keck J, Kilburn D, Streblow A, Egger J, et al.
JCO Precis Oncol
. 2024 Jun;
8:e2300686.
PMID: 38905574
Case report of a HER2-expressed ovarian clear cell carcinoma with exceptional response to trastuzumab deruxtecan.
2.
Johnson B, Creason A, Stommel J, Keck J, Parmar S, Betts C, et al.
Cell Rep Med
. 2022 Mar;
3(2):100525.
PMID: 35243422
Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms...
3.
Patel D, Ahmad F, Kambach D, Sun Q, Halim A, Kramp T, et al.
Sci Rep
. 2019 Oct;
9(1):15458.
PMID: 31664073
Cholesterol is a critical component of membranes and a precursor for hormones and other signaling molecules. Previously, we showed that unlike astrocytes, glioblastoma cells do not downregulate cholesterol synthesis when...
4.
Ahmad F, Sun Q, Patel D, Stommel J
Cancers (Basel)
. 2019 Jan;
11(2).
PMID: 30691162
Glioblastoma is a highly lethal adult brain tumor with no effective treatments. In this review, we discuss the potential to target cholesterol metabolism as a new strategy for treating glioblastomas....
5.
Yuen G, Khan F, Gao S, Stommel J, Batchelor E, Wu X, et al.
Nucleic Acids Res
. 2017 Oct;
45(20):12039-12053.
PMID: 29036671
CRISPR/Cas9 is a powerful gene editing tool for gene knockout studies and functional genomic screens. Successful implementation of CRISPR often requires Cas9 to elicit efficient target knockout in a population...
6.
Porter J, Fisher B, Baranello L, Liu J, Kambach D, Nie Z, et al.
Mol Cell
. 2017 Sep;
67(6):1013-1025.e9.
PMID: 28867293
In response to stresses, cells often halt normal cellular processes, yet stress-specific pathways must bypass such inhibition to generate effective responses. We investigated how cells redistribute global transcriptional activity in...
7.
Eke I, Makinde A, Aryankalayil M, Sandfort V, Palayoor S, Rath B, et al.
Mol Cancer Ther
. 2017 Aug;
17(2):355-367.
PMID: 28802252
Implementing targeted drug therapy in radio-oncologic treatment regimens has greatly improved the outcome of cancer patients. However, the efficacy of molecular targeted drugs such as inhibitory antibodies or small molecule...
8.
Kambach D, Halim A, Cauer A, Sun Q, Tristan C, Celiku O, et al.
Oncotarget
. 2017 Jan;
8(9):14860-14875.
PMID: 28118603
A hallmark of cellular transformation is the evasion of contact-dependent inhibition of growth. To find new therapeutic targets for glioblastoma, we looked for pathways that are inhibited by high cell...
9.
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, et al.
Genes Dev
. 2011 Mar;
25(7):717-29.
PMID: 21406549
Macroautophagy (autophagy) is a regulated catabolic pathway to degrade cellular organelles and macromolecules. The role of autophagy in cancer is complex and may differ depending on tumor type or context....
10.
Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, et al.
Cancer Cell
. 2010 Aug;
18(2):147-59.
PMID: 20708156
Mdm2 is the major negative regulator of the p53 pathway. Here, we report that Mdm2 is rapidly degraded after DNA damage and that phosphorylation of Mdm2 by casein kinase I...