Jayaraj Rajagopal
Overview
Explore the profile of Jayaraj Rajagopal including associated specialties, affiliations and a list of published articles.
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69
Citations
5599
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Recent Articles
11.
Sikkema L, Ramirez-Suastegui C, Strobl D, Gillett T, Zappia L, Madissoon E, et al.
Nat Med
. 2023 Jun;
29(6):1563-1577.
PMID: 37291214
Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can...
12.
Reedy J, Jensen K, Crossen A, Basham K, Ward R, Reardon C, et al.
bioRxiv
. 2023 Apr;
PMID: 37034634
Respiratory infections caused by the human fungal pathogen are a major cause of mortality for immunocompromised patients. Exposure to these pathogens occurs through inhalation, although the role of the respiratory...
13.
Shah V, Hou J, Vinarsky V, Xu J, Surve M, Lin C, et al.
Elife
. 2023 Mar;
12.
PMID: 36994985
The specific functional properties of a tissue are distributed amongst its component cell types. The various cells act coherently, as an ensemble, in order to execute a physiologic response. Modern...
14.
Crossen A, Ward R, Reedy J, Surve M, Klein B, Rajagopal J, et al.
J Fungi (Basel)
. 2023 Jan;
9(1).
PMID: 36675861
The lung epithelial lining serves as the primary barrier to inhaled environmental toxins, allergens, and invading pathogens. Pulmonary fungal infections are devastating and carry high mortality rates, particularly in those...
15.
Onorati A, Havas A, Lin B, Rajagopal J, Sen P, Adams P, et al.
Mol Cell Biol
. 2022 Sep;
42(10):e0017122.
PMID: 36154662
Cellular senescence is a stable form of cell cycle arrest associated with proinflammatory responses. Senescent cells can be cleared by the immune system as a part of normal tissue homeostasis....
16.
Shah V, Chivukula R, Lin B, Waghray A, Rajagopal J
Annu Rev Pathol
. 2021 Aug;
17:23-46.
PMID: 34437820
Cystic fibrosis (CF) is caused by defects in an anion channel, the cystic fibrosis transmembrane conductance regulator (CFTR). Recently, a new airway epithelial cell type has been discovered and dubbed...
17.
Delorey T, Ziegler C, Heimberg G, Normand R, Yang Y, Segerstolpe A, et al.
Nature
. 2021 Apr;
595(7865):107-113.
PMID: 33915569
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure, but little is known about its pathophysiology. Here we generated single-cell atlases of...
18.
Mou H, Yang Y, Riehs M, Barrios J, Shivaraju M, Haber A, et al.
Cell Rep
. 2021 Apr;
35(3):109011.
PMID: 33882306
Pulmonary neuroendocrine cells (PNECs) have crucial roles in airway physiology and immunity by producing bioactive amines and neuropeptides (NPs). A variety of human diseases exhibit PNEC hyperplasia. Given accumulated evidence...
19.
Delorey T, Ziegler C, Heimberg G, Normand R, Yang Y, Segerstolpe A, et al.
bioRxiv
. 2021 Mar;
PMID: 33655247
The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute lung injury and acute respiratory distress syndrome, or direct complications resulting in multiple-organ failures. Little is...
20.
Shivaraju M, Chitta U, Grange R, Jain I, Capen D, Liao L, et al.
Science
. 2021 Jan;
371(6524):52-57.
PMID: 33384370
Neuroendocrine (NE) cells are epithelial cells that possess many of the characteristics of neurons, including the presence of secretory vesicles and the ability to sense environmental stimuli. The normal physiologic...