Jay Shendure
Overview
Explore the profile of Jay Shendure including associated specialties, affiliations and a list of published articles.
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405
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52146
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Recent Articles
11.
Bunne C, Roohani Y, Rosen Y, Gupta A, Zhang X, Roed M, et al.
Cell
. 2024 Dec;
187(25):7045-7063.
PMID: 39672099
Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to...
12.
Askary A, Chen W, Choi J, Du L, Elowitz M, Gagnon J, et al.
Nat Rev Genet
. 2024 Nov;
26(3):203-222.
PMID: 39587306
A paradigm for biology is emerging in which cells can be genetically programmed to write their histories into their own genomes. These records can subsequently be read, and the cellular...
13.
Attar S, Browning V, Krebs M, Liu Y, Nichols E, Tsue A, et al.
Nat Methods
. 2024 Nov;
22(1):156-165.
PMID: 39548245
In situ hybridization (ISH) is a powerful tool for investigating the spatial arrangement of nucleic acid targets in fixed samples. ISH is typically visualized using fluorophores to allow high sensitivity...
14.
Cox S, Casto A, Franko N, Chow E, Han P, Gamboa L, et al.
Emerg Infect Dis
. 2024 Oct;
30(11):2250-2260.
PMID: 39447143
Congregate homeless shelters are disproportionately affected by infectious disease outbreaks. We describe enterovirus epidemiology across 23 adult and family shelters in King County, Washington, USA, during October 2019-May 2021, by...
15.
Ho C, Dippel M, McQuade M, Mishra A, Pribitzer S, Nguyen L, et al.
bioRxiv
. 2024 Oct;
PMID: 39416200
Genetic variants associated with autoimmune diseases are highly enriched within putative -regulatory regions of CD4 T cells, suggesting that they alter disease risk via changes in gene regulation. However, very...
16.
Bunne C, Roohani Y, Rosen Y, Gupta A, Zhang X, Roed M, et al.
ArXiv
. 2024 Oct;
PMID: 39398201
The cell is arguably the most fundamental unit of life and is central to understanding biology. Accurate modeling of cells is important for this understanding as well as for determining...
17.
Baron C, Mitchell O, Avagyan S, Menard R, Yang S, Robertson A, et al.
bioRxiv
. 2024 Sep;
PMID: 39314385
Hematopoietic stem cells are regulated by endothelial and mesenchymal stromal cells in the marrow niche1-3. Leukemogenesis was long believed to be solely driven by genetic perturbations in hematopoietic cells but...
18.
Chardon F, McDiarmid T, Page N, Daza R, Martin B, Domcke S, et al.
Nat Commun
. 2024 Sep;
15(1):8209.
PMID: 39294132
CRISPR-based gene activation (CRISPRa) is a strategy for upregulating gene expression by targeting promoters or enhancers in a tissue/cell-type specific manner. Here, we describe an experimental framework that combines highly...
19.
Garge R, Lynch V, Fields R, Casadei S, Best S, Stone J, et al.
bioRxiv
. 2024 Sep;
PMID: 39282277
Gastrulation is the highly coordinated process by which the early embryo breaks symmetry, establishes germ layers and a body plan, and sets the stage for organogenesis. As early mammalian development...
20.
Read D, Booth G, Daza R, Jackson D, Gladden R, Srivatsan S, et al.
Commun Biol
. 2024 Aug;
7(1):1052.
PMID: 39187646
Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular...