Jay E Brenman
Overview
Explore the profile of Jay E Brenman including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
2582
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Recent Articles
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Bhagat H, Compton S, Musso D, Laudeman C, Jackson K, Yi N, et al.
PLoS One
. 2018 Oct;
13(10):e0204605.
PMID: 30359371
Obesity and insulin resistance are primary risk factors for Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD is generally exhibited by non-progressive simple steatosis. However, a significant subset of patient's progress to...
3.
Renner S, Walker L, Forsberg L, Sexton J, Brenman J
PLoS One
. 2017 Apr;
12(4):e0176502.
PMID: 28437447
Carbonic anhydrases are a family of enzymes that catalyze the reversible condensation of water and carbon dioxide to carbonic acid, which spontaneously dissociates to bicarbonate. Carbonic anhydrase III (Car3) is...
4.
Sinnett S, Brenman J
Exp Suppl
. 2016 Nov;
107:389-401.
PMID: 27812989
In the fruit fly, Drosophila melanogaster, mono-allelic expression of AMPK-α, -β, and -γ yields a single heterotrimeric energy sensor that regulates cellular and whole-body energetic homeostasis. The genetic simplicity of...
5.
Onyenwoke R, Brenman J
J Exp Neurosci
. 2016 Apr;
9(Suppl 2):81-91.
PMID: 27081317
Autophagy is a complex pathway regulated by numerous signaling events that recycles macromolecules and can be perturbed in lysosomal storage diseases (LSDs). The concept of LSDs, which are characterized by...
6.
Yi N, He Q, Caligan T, Smith G, Forsberg L, Brenman J, et al.
Assay Drug Dev Technol
. 2015 Oct;
13(9):558-69.
PMID: 26505612
Diabetes currently affects 9.3% of the U.S. population totaling $245 billion annually in U.S. direct and indirect healthcare costs. Current therapies for diabetes are limited in their ability to control...
7.
Onyenwoke R, Sexton J, Yan F, Diaz M, Forsberg L, Major M, et al.
Biochem J
. 2015 Jul;
470(3):331-42.
PMID: 26195823
Autophagy is a complex pathway regulated by numerous signalling events that recycles macromolecules and may be perturbed in lysosomal storage disorders (LSDs). During autophagy, aberrant regulation of the lysosomal Ca(2+)...
8.
Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators
Sinnett S, Brenman J
Pharmacol Ther
. 2014 Mar;
143(1):111-8.
PMID: 24583089
AMP-activated protein kinase (AMPK) is a promising therapeutic target for cancer, type II diabetes, and other illnesses characterized by abnormal energy utilization. During the last decade, numerous labs have published...
9.
Sinnett S, Sexton J, Brenman J
Curr Chem Genom Transl Med
. 2014 Jan;
7:30-8.
PMID: 24396733
AMPK is a conserved heterotrimeric serine-threonine kinase that regulates anabolic and catabolic pathways in eukaryotes. Its central role in cellular and whole body metabolism makes AMPK a commonly proposed therapeutic...
10.
Swick L, Kazgan N, Onyenwoke R, Brenman J
Biol Open
. 2013 Dec;
2(12):1321-3.
PMID: 24337116
The maintenance of energetic homeostasis in the face of limited available nutrients is a complex problem faced by all organisms. One important mechanism to maintain energetic homeostasis involves the activation...