Jonathan Z Sexton
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Explore the profile of Jonathan Z Sexton including associated specialties, affiliations and a list of published articles.
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72
Citations
949
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Recent Articles
1.
Hung A, Zhang C, Sexton J, OMeara M, Welch J
bioRxiv
. 2024 Nov;
PMID: 39574699
The rapid advancement of high-content, single-cell technologies like robotic confocal microscopy with multiplexed dyes (morphological profiling) can be leveraged to reveal fundamental biology, ranging from microbial and abiotic stress to...
2.
Meyer S, Zhang C, Garcia M, Procario M, Yoo S, Jolly A, et al.
Gastro Hep Adv
. 2024 Nov;
3(8):1045-1053.
PMID: 39529647
Background And Aims: Drug-induced liver injury (DILI) is a major failure mode in pharmaceutical development. This study aims to address the limitations of existing preclinical models by assessing a high-throughput,...
3.
Armbruster K, Jiang J, Sartorio M, Scott N, Peterson J, Sexton J, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(46):e2410909121.
PMID: 39495918
Members of the Bacteroidota compose a large portion of the human gut microbiota, contributing to overall gut health via the degradation of various polysaccharides. This process is facilitated by lipoproteins,...
4.
Tapaswi A, Cemalovic N, Polemi K, Sexton J, Colacino J
Toxicol In Vitro
. 2024 Sep;
101:105935.
PMID: 39243829
The general population is exposed to many chemicals which have putative, but incompletely understood, links to breast cancer. Cell Painting is a high-content imaging-based in vitro assay that allows for...
5.
Reynolds M, Klein B, McFadden M, Judge N, Navarrete H, Michmerhuizen B, et al.
Cell Rep
. 2024 Aug;
43(8):114607.
PMID: 39126652
Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of coordinating metabolic and inflammatory programs during infection are poorly defined. Here, we show that type I interferon (IFN) temporally...
6.
Schroeder J, Polemi K, Tapaswi A, Svoboda L, Sexton J, Colacino J
Front Oncol
. 2024 Jun;
14:1411295.
PMID: 38915368
Introduction: Breast cancer is the second most diagnosed cancer, as well as the primary cause of cancer death in women worldwide. Of the different breast cancer subtypes, triple-negative breast cancer...
7.
Armbruster K, Jiang J, Sartorio M, Scott N, Peterson J, Sexton J, et al.
bioRxiv
. 2024 Jun;
PMID: 38853980
Members of the Bacteroidota compose a large portion of the human gut microbiota, contributing to overall gut health via the degradation of various polysaccharides. This process is facilitated by lipoproteins,...
8.
Tapaswi A, Cemalovic N, Polemi K, Sexton J, Colacino J
bioRxiv
. 2024 May;
PMID: 38746407
There are a substantial number of chemicals to which individuals in the general population are exposed which have putative, but still poorly understood, links to breast cancer. Cell Painting is...
9.
Arya S, Collie S, Xu Y, Fernandez M, Sexton J, Mosalaganti S, et al.
bioRxiv
. 2024 May;
PMID: 38712240
Acute inflammation, characterized by a rapid influx of neutrophils, is a protective response that can lead to chronic inflammatory diseases when left unresolved. Secretion of LTB -containing exosomes is required...
10.
Sun X, Huang X, Park K, Zhou X, Kennedy A, Pretto C, et al.
ACS Nano
. 2024 Apr;
18(15):10439-10453.
PMID: 38567994
The cGAS-STING pathway plays a crucial role in innate immune activation against cancer and infections, and STING agonists based on cyclic dinucleotides (CDN) have garnered attention for their potential use...