Jay E Brenman
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Explore the profile of Jay E Brenman including associated specialties, affiliations and a list of published articles.
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29
Citations
2582
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Recent Articles
11.
Kern J, Zhang Y, Kramer S, Brenman J, Rasse T
Genetics
. 2013 Jun;
195(1):59-72.
PMID: 23770702
Kinesin-based transport is important for synaptogenesis, neuroplasticity, and maintaining synaptic function. In an anatomical screen of neurodevelopmental mutants, we identified the exchange of a conserved residue (R561H) in the forkhead-associated...
12.
Klionsky D, Abdalla F, Abeliovich H, Abraham R, Acevedo-Arozena A, Adeli K, et al.
Autophagy
. 2012 Sep;
8(4):445-544.
PMID: 22966490
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered...
13.
Braco J, Gillespie E, Alberto G, Brenman J, Johnson E
Genetics
. 2012 Jul;
192(2):457-66.
PMID: 22798489
Adipokinetic hormone (AKH) is the equivalent of mammalian glucagon, as it is the primary insect hormone that causes energy mobilization. In Drosophila, current knowledge of the mechanisms regulating AKH signaling...
14.
Onyenwoke R, Forsberg L, Liu L, Williams T, Alzate O, Brenman J
Mol Biol Cell
. 2011 Nov;
23(2):381-9.
PMID: 22114351
AMP-activated protein kinase (AMPK) is a key energy sensor that regulates metabolism to maintain cellular energy balance. AMPK activation has also been proposed to mimic benefits of caloric restriction and...
15.
Williams T, Courchet J, Viollet B, Brenman J, Polleux F
Proc Natl Acad Sci U S A
. 2011 Mar;
108(14):5849-54.
PMID: 21436046
Mammalian brain connectivity requires the coordinated production and migration of billions of neurons and the formation of axons and dendrites. The LKB1/Par4 kinase is required for axon formation during cortical...
16.
Sexton J, He Q, Forsberg L, Brenman J
Int J High Throughput Screen
. 2010 Dec;
2010(1):127-140.
PMID: 21132080
Peroxisomes are ubiquitous cellular organelles that perform vital functions including fatty acid beta-oxidation, plasmalogen synthesis, and detoxification of harmful oxidative species. In rodents numerous compounds that increase peroxisome biogenesis also...
17.
Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila
Johnson E, Kazgan N, Bretz C, Forsberg L, Hector C, Worthen R, et al.
PLoS One
. 2010 Sep;
5(9).
PMID: 20862213
Organisms must utilize multiple mechanisms to maintain energetic homeostasis in the face of limited nutrient availability. One mechanism involves activation of the heterotrimeric AMP-activated protein kinase (AMPK), a cell-autonomous sensor...
18.
Kazgan N, Williams T, Forsberg L, Brenman J
Mol Biol Cell
. 2010 Aug;
21(19):3433-42.
PMID: 20685962
The metabolic regulator AMP-activated protein kinase (AMPK) maintains cellular homeostasis through regulation of proteins involved in energy-producing and -consuming pathways. Although AMPK phosphorylation targets include cytoplasmic and nuclear proteins, the...
19.
Williams T, Forsberg L, Viollet B, Brenman J
Autophagy
. 2009 Oct;
5(8):1155-65.
PMID: 19844161
When ATP levels in a cell decrease, various homeostatic intracellular mechanisms initiate attempts to restore ATP levels. As a prominent energy sensor, AMP-activated protein kinase (AMPK) represents one molecular gauge...
20.