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» Authors » Javier Merino-Gracia

Javier Merino-Gracia

Explore the profile of Javier Merino-Gracia including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 70
Followers 0
Related Specialties
Biochemistry
Neurology
Pharmacology
Top 10 Co-Authors
Ignacio Rodriguez-Crespo
Carlos Costas-Insua
Marta Bruix
Susan Kathleen Fetics
Angeles Canales
Clara Aicart-Ramos
Martin Caffrey
Jonathan Bailey
Peter Rapali
Irene B Maroto
Published In
FEBS J
J Biol Chem
Anal Chem
Neuropharmacology
Adv Protein Chem Struct Biol
Affiliations
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Recent Articles
1.
Selective inhibition of cannabinoid CB receptor-evoked signalling by the interacting protein GAP43
Maroto I, Moreno E, Costas-Insua C, Merino-Gracia J, Diez-Alarcia R, Alvaro-Blazquez A, et al.
Neuropharmacology . 2023 Sep; 240:109712. PMID: 37689260
Cannabinoids exert pleiotropic effects on the brain by engaging the cannabinoid CB receptor (CBR), a presynaptic metabotropic receptor that regulates key neuronal functions in a highly context-dependent manner. We have...
2.
Membrane (and Soluble) Protein Stability and Binding Measurements in the Lipid Cubic Phase Using Label-Free Differential Scanning Fluorimetry
Boland C, Olatunji S, Bailey J, Howe N, Weichert D, Fetics S, et al.
Anal Chem . 2018 Sep; 90(20):12152-12160. PMID: 30180556
Label-free differential scanning fluorimetry (DSF) is a relatively new method for evaluating the stability of proteins. It can be used as a screening tool for downstream applications such as crystallization....
3.
Subcellular Targeting of Nitric Oxide Synthases Mediated by Their N-Terminal Motifs
Costas-Insua C, Merino-Gracia J, Aicart-Ramos C, Rodriguez-Crespo I
Adv Protein Chem Struct Biol . 2018 Feb; 111:165-195. PMID: 29459031
From a catalytic point of view, the three mammalian nitric oxide synthases (NOSs) function in an almost identical way. The N-terminal oxygenase domain catalyzes the conversion of l-arginine to l-citrulline...
4.
Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB
Merino-Gracia J, Zamora-Carreras H, Bruix M, Rodriguez-Crespo I
J Biol Chem . 2016 Aug; 291(40):20962-20975. PMID: 27502274
It has been suggested that DYNLT1, a dynein light chain known to bind to various cellular and viral proteins, can function both as a molecular clamp and as a microtubule-cargo...
5.
Insights into the C-terminal Peptide Binding Specificity of the PDZ Domain of Neuronal Nitric-oxide Synthase: CHARACTERIZATION OF THE INTERACTION WITH THE TIGHT JUNCTION PROTEIN CLAUDIN-3
Merino-Gracia J, Costas-Insua C, Canales M, Rodriguez-Crespo I
J Biol Chem . 2016 Apr; 291(22):11581-95. PMID: 27030110
Neuronal nitric-oxide synthase, unlike its endothelial and inducible counterparts, displays a PDZ (PSD-95/Dlg/ZO-1) domain located at its N terminus involved in subcellular targeting. The C termini of various cellular proteins...
6.
DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor
Merino-Gracia J, Garcia-Mayoral M, Rapali P, Valero R, Bruix M, Rodriguez-Crespo I
FEBS J . 2015 Aug; 282(20):3945-58. PMID: 26227614
It has been suggested that DYNLT, a dynein light chain known to bind to various cellular and viral proteins, can function as a microtubule-cargo adaptor. Recent data showed that DYNLT...
7.
The association of viral proteins with host cell dynein components during virus infection
Merino-Gracia J, Garcia-Mayoral M, Rodriguez-Crespo I
FEBS J . 2011 Jul; 278(17):2997-3011. PMID: 21777384
After fusion with the cellular plasma membrane or endosomal membranes, viral particles are generally too large to diffuse freely within the crowded cytoplasm environment. Thus, they will never reach the...