Javier Apfeld
Overview
Explore the profile of Javier Apfeld including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1737
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Recent Articles
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2.
Servello F, Fernandes R, Eder M, Harris N, Martin O, Oswal N, et al.
Elife
. 2022 Oct;
11.
PMID: 36226814
Hydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet...
3.
Schiffer J, Stumbur S, Seyedolmohadesin M, Xu Y, Serkin W, McGowan N, et al.
PLoS Pathog
. 2021 Dec;
17(12):e1010112.
PMID: 34941962
Hydrogen peroxide (H2O2) is the most common chemical threat that organisms face. Here, we show that H2O2 alters the bacterial food preference of Caenorhabditis elegans, enabling the nematodes to find...
4.
Stanley J, Johnsen S, Apfeld J
Sci Rep
. 2020 Oct;
10(1):16843.
PMID: 33033364
Two-state ratiometric biosensors change conformation and spectral properties in response to specific biochemical inputs. Much effort over the past two decades has been devoted to engineering biosensors specific for ions,...
5.
Schiffer J, Servello F, Heath W, Amrit F, Stumbur S, Eder M, et al.
Elife
. 2020 May;
9.
PMID: 32367802
Hydrogen peroxide is the preeminent chemical weapon that organisms use for combat. Individual cells rely on conserved defenses to prevent and repair peroxide-induced damage, but whether similar defenses might be...
6.
Apfeld J, Alper S
Methods Mol Biol
. 2018 Feb;
1706:53-75.
PMID: 29423793
Numerous approaches have been taken in the hunt for human disease genes. The identification of such genes not only provides a great deal of information about the mechanism of disease...
7.
Apfeld J, Fontana W
Biology (Basel)
. 2018 Jan;
7(1).
PMID: 29295479
It is often assumed, but not established, that the major neurodegenerative diseases, such as Parkinson's disease, are not just age-dependent (their incidence changes with time) but actually aging-dependent (their incidence...
8.
Stroustrup N, Anthony W, Nash Z, Gowda V, Gomez A, Lopez-Moyado I, et al.
Nature
. 2016 Jan;
530(7588):103-7.
PMID: 26814965
The process of ageing makes death increasingly likely, involving a random aspect that produces a wide distribution of lifespan even in homogeneous populations. The study of this stochastic behaviour may...
9.
Bordone L, Motta M, Picard F, Robinson A, Jhala U, Apfeld J, et al.
PLoS Biol
. 2015 Dec;
13(12):e1002346.
PMID: 26714029
No abstract available.
10.
Romero-Aristizabal C, Marks D, Fontana W, Apfeld J
Nat Commun
. 2014 Sep;
5:5020.
PMID: 25262602
Cells adjust their behaviour in response to redox events by regulating protein activity through the reversible formation of disulfide bridges between cysteine thiols. However, the spatial and temporal control of...