Jason T George
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Explore the profile of Jason T George including associated specialties, affiliations and a list of published articles.
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34
Citations
668
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Recent Articles
1.
Shrestha P, Ghoreyshi Z, George J
Sci Rep
. 2025 Mar;
15(1):7308.
PMID: 40025156
Metastatic disease is the leading cause of cancer-related death, despite recent advances in therapeutic interventions. Prior modeling approaches have accounted for the adaptive immune system's role in combating tumors, which...
2.
Teimouri H, Ghoreyshi Z, Kolomeisky A, George J
Front Immunol
. 2025 Feb;
15:1510435.
PMID: 39916960
Introduction: T-cell receptors (TCRs) play a critical role in the immune response by recognizing specific ligand peptides presented by major histocompatibility complex (MHC) molecules. Accurate prediction of peptide binding to...
3.
Ghoreyshi Z, Teimouri H, Kolomeisky A, George J
Biophys J
. 2024 Nov;
123(23):4115-4122.
PMID: 39520055
T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) interactions that result in T cell activation are complex and have been distinguished by their equilibrium affinity and kinetic profiles. While...
4.
Fan Y, Chiu A, Zhao F, George J
Oncotarget
. 2024 Nov;
15:768-781.
PMID: 39513932
Modern cancer management comprises a variety of treatment strategies. Immunotherapy, while successful at treating many cancer subtypes, is often hindered by tumor immune evasion and T cell exhaustion as a...
5.
Teimouri H, Ghoreyshi Z, Kolomeisky A, George J
bioRxiv
. 2024 Oct;
PMID: 39416168
T-cell receptors (TCRs) play a critical role in the immune response by recognizing specific ligand peptides presented by major histocompatibility complex (MHC) molecules. Accurate prediction of peptide binding to TCRs...
6.
Jain P, Kizhuttil R, Nair M, Bhatia S, Thompson E, George J, et al.
iScience
. 2024 Jul;
27(7):110310.
PMID: 39055927
Cancer cell populations comprise phenotypes distributed among the epithelial-mesenchymal (E-M) spectrum. However, it remains unclear which population-level processes give rise to the observed experimental distribution and dynamical changes in E-M...
7.
Wang A, Lin X, Chau K, Onuchic J, Levine H, George J
Sci Adv
. 2024 May;
10(20):eadl0161.
PMID: 38748791
Reliable prediction of T cell specificity against antigenic signatures is a formidable task, complicated by the immense diversity of T cell receptor and antigen sequence space and the resulting limited...
8.
Najafi A, Jolly M, George J
STAR Protoc
. 2024 Jan;
5(1):102819.
PMID: 38183653
The epithelial-to-mesenchymal transition (EMT) provides crucial insights into the metastatic process and possesses prognostic value within the cancer context. Here, we present COMET, an R package for inferring EMT trajectories...
9.
George J
Biophys J
. 2023 Oct;
122(22):4414-4424.
PMID: 37876159
Phenotypic adaptation is a universal feature of biological systems navigating highly variable environments. Recent empirical data support the role of memory-driven decision making in cellular systems navigating uncertain future nutrient...
10.
Ghoreyshi Z, George J
Front Immunol
. 2023 Oct;
14:1228873.
PMID: 37781387
T cell receptor (TCR)-peptide-major histocompatibility complex (pMHC) interactions play a vital role in initiating immune responses against pathogens, and the specificity of TCRpMHC interactions is crucial for developing optimized therapeutic...