Daniele Piomelli
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Explore the profile of Daniele Piomelli including associated specialties, affiliations and a list of published articles.
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346
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14025
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Recent Articles
1.
Argueta D, Avalos B, Goel Y, Tran H, Fotio Y, Piomelli D, et al.
Blood Adv
. 2025 Mar;
PMID: 40085960
Chronic and acute pain are major comorbidities of sickle cell disease (SCD). Both peripheral and central nervous system mechanisms underlie SCD pain. We investigated the potential roles of endogenous fatty...
2.
Mabou Tagne A, Fotio Y, Lee H, Jung K, Katz J, Ahmed F, et al.
bioRxiv
. 2025 Feb;
PMID: 39975205
Acute injuries can progress into painful states that endure long after healing. The mechanism underlying this transition remains unclear, but metabolic adaptations to the bioenergy demands imposed by injury are...
3.
Lallai V, Lam T, Garcia-Milian R, Chen Y, Fowler J, Manca L, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334909
Given the increasing use of cannabis in the US, there is an urgent need to better understand the drug's effects on central signaling mechanisms. Extracellular vesicles (EVs) have been identified...
4.
Goodman M, Lombardi C, Torrens A, Bresee C, Saloman J, Li L, et al.
Cannabis Cannabinoid Res
. 2024 Sep;
10(1):60-70.
PMID: 39291350
This investigation examined the association of pancreatitis and pancreatitis-related pain with serum levels of two endocannabinoid molecules such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and two paracannabinoid molecules such as...
5.
Squire E, Lee H, Jeong W, Lee S, Ravichandiran V, Limoli C, et al.
Neuropharmacology
. 2024 Sep;
261:110142.
PMID: 39241906
Gulf War Illness (GWI) is a chronic disorder characterized by a heterogeneous set of symptoms that include pain, fatigue, anxiety, and cognitive impairment. These are thought to stem from damage...
6.
Torrens A, Mabou Tagne A, Tran A, Ahmed F, Huestis M, Piomelli D
Cannabis Cannabinoid Res
. 2024 Aug;
9(6):1537-1542.
PMID: 39162003
Animal studies suggest that adolescent exposure to Δ-tetrahydrocannabinol (Δ-THC), the intoxicating constituent of cannabis, causes lasting functional alterations in brain and other organs. Those studies often neglect the impact that...
7.
Mabou Tagne A, Fotio Y, Gupta K, Piomelli D
J Pharmacol Exp Ther
. 2024 Jul;
391(2):174-181.
PMID: 38955494
People with sickle cell disease (SCD) often experience chronic pain as well as unpredictable episodes of acute pain, which significantly affects their quality of life and life expectancy. Current treatment...
8.
Jung K, Lin L, Piomelli D
Cells
. 2024 Mar;
13(5.
PMID: 38474425
Cannabis use stimulates calorie intake, but epidemiological studies show that people who regularly use it are leaner than those who don't. Two explanations have been proposed for this paradoxical finding....
9.
Fotio Y, Mabou Tagne A, Squire E, Lee H, Phillips C, Chang K, et al.
Nat Commun
. 2024 Feb;
15(1):1705.
PMID: 38402219
Circulating monocytes participate in pain chronification but the molecular events that cause their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show that monocytes enable progression...
10.
Butini S, Grether U, Jung K, Ligresti A, Allara M, Postmus A, et al.
J Med Chem
. 2024 Jan;
67(3):1758-1782.
PMID: 38241614
New potent, selective monoacylglycerol lipase (MAGL) inhibitors based on the azetidin-2-one scaffold ((±)--, (±)--, and (±)--) were developed as irreversible ligands, as demonstrated by enzymatic and crystallographic studies for (±)-,...