Jason N Kuehner
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Explore the profile of Jason N Kuehner including associated specialties, affiliations and a list of published articles.
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12
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545
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Recent Articles
1.
Graber J, Hoskinson D, Liu H, Michaels K, Benson P, Maki N, et al.
Genetics
. 2023 Nov;
226(2).
PMID: 37967370
The Pcf11 protein is an essential subunit of the large complex that cleaves and polyadenylates eukaryotic mRNA precursor. It has also been functionally linked to gene-looping, termination of RNA Polymerase...
2.
Amodeo M, Mitchell S, Pavan V, Kuehner J
G3 (Bethesda)
. 2022 Oct;
13(1).
PMID: 36315099
Premature transcription termination (i.e. attenuation) is a potent gene regulatory mechanism that represses mRNA synthesis. Attenuation of RNA polymerase II is more prevalent than once appreciated, targeting 10-15% of mRNA...
3.
4.
Whalen C, Tuohy C, Tallo T, Kaufman J, Moore C, Kuehner J
G3 (Bethesda)
. 2018 Apr;
8(6):2043-2058.
PMID: 29686108
Termination of RNA Polymerase II (Pol II) activity serves a vital cellular role by separating ubiquitous transcription units and influencing RNA fate and function. In the yeast , Pol II...
5.
Kuehner J, Kaufman J, Moore C
DNA Repair (Amst)
. 2017 Aug;
57:151-160.
PMID: 28783563
The quality and retrieval of genetic information is imperative to the survival and reproduction of all living cells. Ultraviolet (UV) light induces lesions that obstruct DNA access during transcription, replication,...
6.
Graber J, Nazeer F, Yeh P, Kuehner J, Borikar S, Hoskinson D, et al.
Genome Res
. 2013 Jun;
23(10):1690-703.
PMID: 23788651
Systemic response to DNA damage and other stresses is a complex process that includes changes in the regulation and activity of nearly all stages of gene expression. One gene regulatory...
7.
Gordon J, Shikov S, Kuehner J, Liriano M, Lee E, Stafford W, et al.
Biochemistry
. 2011 Oct;
50(47):10203-14.
PMID: 22026644
Yeast cleavage factor I (CF I) is an essential complex of five proteins that binds signal sequences at the 3' end of yeast mRNA. CF I is required for correct...
8.
Kuehner J, Pearson E, Moore C
Nat Rev Mol Cell Biol
. 2011 Apr;
12(5):283-94.
PMID: 21487437
The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II (Pol II)-mediated transcription, and termination of its activity is necessary to partition the genome and...
9.
Cloud-Hansen K, Kuehner J, Tong L, Miller S, Handelsman J
CBE Life Sci Educ
. 2008 Sep;
7(3):302-9.
PMID: 18765752
The goal of the work reported here was to help students expand their understanding of antibiotic resistance, the Central Dogma, and evolution. We developed a unit entitled "Ciprofloxacin Resistance in...
10.
Kuehner J, Brow D
Mol Cell
. 2008 Jul;
31(2):201-11.
PMID: 18657503
Guanine nucleotide negatively regulates yeast inosine monophosphate dehydrogenase (IMPDH) mRNA synthesis by an unknown mechanism. IMPDH catalyzes the first dedicated step of GTP biosynthesis, and feedback control of its expression...