Jason M Zimmerer
Overview
Explore the profile of Jason M Zimmerer including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
329
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Recent Articles
1.
Zimmerer J, Chaudhari S, Koneru K, Han J, Abdel-Rasoul M, Uwase H, et al.
Transplant Direct
. 2025 Jan;
11(2):e1742.
PMID: 39802197
Background: Alloprimed antibody-suppressor CXCR5CD8 T cells (CD8 T cells) downregulate alloantibody production, mediate cytotoxicity of IgG B cells, and prolong allograft survival. The purpose of this investigation was to determine...
2.
Han J, Zimmerer J, Zeng Q, Chaudhari S, Satoskar A, Abdel-Rasoul M, et al.
J Immunol
. 2024 Mar;
212(9):1504-1518.
PMID: 38517294
Adoptive cell therapy (ACT), especially with CD4+ regulatory T cells (CD4+ Tregs), is an emerging therapeutic strategy to minimize immunosuppression and promote long-term allograft acceptance, although much research remains to...
3.
Han J, Zimmerer J, Zeng Q, Chaudhari S, Hart M, Satoskar A, et al.
Transplantation
. 2023 Oct;
108(3):679-692.
PMID: 37872660
Background: Adoptive cellular therapy (ACT) with antibody-suppressor CXCR5 + CD8 + T cells (CD8 + T Ab-supp ) inhibits alloantibody production, antibody-mediated rejection (AMR), and prolongs graft survival in multiple...
4.
Zimmerer J, Han J, Peterson C, Zeng Q, Ringwald B, Cassol C, et al.
Am J Transplant
. 2022 Feb;
22(6):1550-1563.
PMID: 35114045
CCR5 KO kidney transplant (KTx) recipients are extraordinarily high alloantibody producers and develop pathology that mimics human antibody-mediated rejection (AMR). C57BL/6 and CCR5 KO mice (H-2 ) were transplanted with...
5.
Zimmerer J, Ringwald B, Chaudhari S, Han J, Peterson C, Warren R, et al.
J Immunol
. 2021 Nov;
207(12):3107-3121.
PMID: 34810223
Hepatocyte transplant represents a treatment for metabolic disorders but is limited by immunogenicity. Our prior work identified the critical role of CD8 T cells, with or without CD4 T cell...
6.
Elzein S, Zimmerer J, Han J, Ringwald B, Bumgardner G
J Immunol
. 2021 Oct;
206(12):2775-2783.
PMID: 34602651
CD8 T cells have conventionally been studied in relationship to pathogen or tumor clearance. Recent reports have identified novel functions of CXCR5CD8 T cells that can home to lymphoid follicles,...
7.
Zimmerer J, Basinger M, Ringwald B, Abdel-Rasoul M, Pelletier R, Rajab A, et al.
Transplantation
. 2020 Feb;
104(11):2424-2434.
PMID: 32032292
Background: We recently reported that a novel CXCR5IFN-γCD8 T-cell subset significantly inhibits posttransplant alloantibody production in a murine transplant model. These findings prompted the current study to investigate the association...
8.
Zimmerer J, Ringwald B, Elzein S, Avila C, Warren R, Abdel-Rasoul M, et al.
Transplantation
. 2019 Mar;
103(9):1809-1820.
PMID: 30830040
Background: We previously reported the novel activity of alloprimed CD8 T cells that suppress posttransplant alloantibody production. The purpose of the study is to investigate the expression and role of...
9.
Zimmerer J, Liu X, Blaszczak A, Avila C, Pham T, Warren R, et al.
J Immunol
. 2018 Nov;
201(12):3731-3740.
PMID: 30397035
Humoral alloimmunity negatively impacts both short- and long-term cell and solid organ transplant survival. We previously reported that alloantibody-mediated rejection of transplanted hepatocytes is critically dependent on host macrophages. However,...
10.
Zimmerer J, Horne P, Fisher M, Pham T, Lunsford K, Ringwald B, et al.
Transplantation
. 2016 Jul;
100(9):1907-15.
PMID: 27379551
Background: The liver immune environment is tightly regulated to balance immune activation with immune tolerance. Understanding the dominant immune pathways initiated in the liver is important because the liver is...