CXCR5CD8 T Cells: A Review of Their Antibody Regulatory Functions and Clinical Correlations

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2021 Oct 4

PMID 34602651

Citations 8

Authors

Steven M Elzein

Jason M Zimmerer

Jing L Han

Bryce A Ringwald

Ginny L Bumgardner

Affiliations

Soon will be listed here.

Abstract

CD8 T cells have conventionally been studied in relationship to pathogen or tumor clearance. Recent reports have identified novel functions of CXCR5CD8 T cells that can home to lymphoid follicles, a key site of antibody production. In this review we provide an in-depth analysis of conflicting reports regarding the impact of CXCR5CD8 T cells on antibody production and examine the data supporting a role for antibody-enhancement (B cell "helper") and antibody-downregulation (antibody-suppressor) by CXCR5CD8 T cell subsets. CXCR5CD8 T cell molecular phenotypes are associated with CD8-mediated effector functions including distinct subsets that regulate antibody responses. Co-inhibitory molecule PD-1, among others, distinguish CXCR5CD8 T cell subsets. We also provide the first in-depth review of human CXCR5CD8 T cells in the context of clinical outcomes and discuss the potential utility of monitoring the quantity of peripheral blood or tissue infiltrating CXCR5CD8 T cells as a prognostic tool in multiple disease states.

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