Jason Laskey
Overview
Explore the profile of Jason Laskey including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
380
Followers
0
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Recent Articles
1.
Chang W, Altman M, Lesburg C, Perera S, Piesvaux J, Schroeder G, et al.
J Med Chem
. 2022 Mar;
65(7):5675-5689.
PMID: 35332774
Stereochemically and structurally complex cyclic dinucleotide-based stimulator of interferon genes (STING) agonists were designed and synthesized to access a previously unexplored chemical space. The assessment of biochemical affinity and cellular...
2.
Perera S, Kopinja J, Ma Y, Muise E, Laskey J, Chakravarthy K, et al.
Mol Cancer Ther
. 2021 Nov;
21(2):282-293.
PMID: 34815361
The innate immune agonist STING (STimulator of INterferon Genes) binds its natural ligand 2'3'-cGAMP (cyclic guanosine-adenosine monophosphate) and initiates type I IFN production. This promotes systemic antigen-specific CD8 T-cell priming...
3.
Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
Wang Y, Zhang K, Georgiev P, Wells S, Xu H, Lacey B, et al.
PLoS One
. 2020 Dec;
15(12):e0243145.
PMID: 33270695
Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-specific Ste20-related serine/threonine kinase, is a negative regulator of signal transduction in immune cells, including T cells, B cells, and dendritic cells (DCs)....
4.
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors
Lacey B, Xu Z, Chai X, Laskey J, Fradera X, Mittal P, et al.
SLAS Discov
. 2020 Aug;
26(1):88-99.
PMID: 32844715
Hematopoietic progenitor kinase 1 (HPK1), also referred to as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1), is a serine/threonine kinase that negatively regulates T-cell signaling by phosphorylating Ser376 of...
5.
Pan B, Perera S, Piesvaux J, Presland J, Schroeder G, Cumming J, et al.
Science
. 2020 Aug;
369(6506).
PMID: 32820094
Pharmacological activation of the STING (stimulator of interferon genes)-controlled innate immune pathway is a promising therapeutic strategy for cancer. Here we report the identification of MSA-2, an orally available non-nucleotide...
6.
McLeod R, Angagaw M, Baral T, Liu L, Moniz R, Laskey J, et al.
Oncotarget
. 2018 Oct;
9(77):34459-34470.
PMID: 30349641
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been reported to mediate both tumorigenic and anti-tumor effects . Blockade of the CEACAM1 signaling pathway has recently been implicated as a...
7.
Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C, et al.
Cancer Discov
. 2014 Aug;
4(10):1154-67.
PMID: 25104330
Unlabelled: Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2 rearrangements leading to constitutive receptor activation were confined to triple-negative...
8.
Zhang W, Zhu J, Efferson C, Ware C, Tammam J, Angagaw M, et al.
Cancer Res
. 2009 Sep;
69(18):7466-72.
PMID: 19738074
Androgen receptors have been shown to play a critical role in prostate cancer. We used ultrasound imaging techniques to track tumor response to antiandrogen and rapamycin treatment in a prostate-specific...